摘要
目的 使用Meta分析评价中药外治法治疗湿疹引起的皮肤瘙痒症的临床疗效。方法 通过检索国内的中国知网、维普、万方数据、Sinomed和国外的Pubmed、Embase、Lilacs、Cochrane等文献数据库,搜索中药外治法治疗湿疹引起的皮肤瘙痒的随机临床试验。检索时间为各数据库建库至2024年12月,由2名评价员分别筛选录入统计学数据,使用Cochrane系统评价手册5.1.0进行偏倚风险评估,应用RevMan5.4.1进行Meta分析。结果 最终纳入14篇文献,共计1 788例患者。与对照组相比,中药外治法(治疗组)对瘙痒评分改善效果更佳(Z=11.88,P<0.000 01)、对湿疹面积和严重程度指数(EASI)评分改善效果更佳(Z=23.15,P<0.000 01)、其临床总有效率更高(Z=6.21,P<0.000 01)、对中医症状的改善效果更佳(Z=5.49,P<0.000 01)、其临床复发率更低(Z=2.88,P=0.004),纳入文献中有3篇提及不良反应,治疗组的不良反应低于对照组。结论 中药外治法治疗湿疹引起的皮肤瘙痒效果优于对照组。由于纳入的文献存在偏倚及异质性,此结论还需更多大样本、多中心、随机、对照、双盲研究加以论证。
Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)external treatment methods in alleviating skin pruritus caused by eczema through a Meta-analysis.Methods Randomized clinical trials investigating the use of TCM external treatment methods for skin pruritus caused by eczema were searched in databases including China National Knowledge Infrastructure(CNKI),VIP,Wanfang,Sinomed,PubMed,Embase,LILACS,and Cochrane,up to December 2024.Two reviewers independently screened and entered the statistical data,conducted bias risk assessment by the Cochrane Handbook for Systematic Reviews of Interventions,version 5.1.0,and performed Meta-analysis using RevMan 5.4.1.Results Ultimately,14 studies involving 1788 patients were included.Compared to the control group,TCM external treatment methods(treatment group)showed better improvement in pruritus scores(Z=11.88,P<0.00001),better improvement in Eczema Area and Severity Index(EASI)scores(Z=23.15,P<0.00001),higher overall clinical efficacy rate(Z=6.21,P<0.00001),better improvement in TCM symptoms(Z=5.49,P<0.00001),and lower clinical recurrence rate(Z=2.88,P=0.004).Three of the included studies mentioned adverse reactions,with the treatment group showing lower adverse reactions than the control group.Conclusion The external treatment of TCM was more effective in treating skin pruritus caused by eczema compared to the control group.Given the biases and heterogeneity in the included literature,this conclusion needs to be further substantiated by more large-scale,multi-center,randomized,controlled,and double-blind studies.
作者
陈婷如
顾秦五风
吴芸杨
孟园园
杨延龙
李睿旻
CHEN Tingru;GU Qinwufeng;WU Yunyang;MENG Yuanyuan;YANG Yanlong;LI Ruimin(The First Affiliated Hospital,Naval Medical University,Shanghai 200433,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)
出处
《药学实践与服务》
2025年第8期383-389,共7页
Journal of Pharmaceutical Practice and Service
基金
上海市“科技创新行动计划”医学创新研究专项项目(23Y31920303)。
关键词
湿疹
瘙痒
中药外治法
META分析
eczema
pruritus
Traditional Chinese Medicine external treatment
Meta-analysis
