摘要
以甲基丙烯酸羟乙酯(HEMA)和聚二甲基硅氧烷(PDMS)为原料,通过共聚反应制备了两亲性聚合物HEMA-PDMS,将其涂覆在经聚乙二醇(PEG)造孔和相转化法得到的聚醚砜(PES)微孔支撑基膜表面,制备了HEMA-PDMS/PES复合膜。利用SEM、FTIR、水接触角测定仪和TGA对其进行了表征与测试,通过气体渗透性实验和溶血率评价了HEMA-PDMS/PES复合膜的CO_(2)、O_(2)渗透率以及溶血性能,考察了吸附温度、吸附时间及牛血清白蛋白(BSA)质量浓度对其吸附性能的影响,探究了其吸附动力学和热力学过程。结果表明,HEMA-PDMS/PES复合膜表面致密无缺陷,400℃前无质量损失,其表面水触角约为40°;HEMA-PDMS/PES复合膜的CO_(2)渗透率是O_(2)渗透率的6.53倍,并具备较低的溶血率(0.207%~0.434%);与未经改性的PDMS/PES复合膜相比,HEMA-PDMS/PES复合膜的BSA最大吸附量最多降低了13.494%;HEMA-PDMS/PES复合膜的吸附等温线符合Langmuir吸附模型和准二级动力学吸附模型,其对BSA的吸附过程为化学吸附,BSA的极性基团与HEMA极性基团相互作用形成的氢键导致BSA吸附在膜表面。
HEMA-PDMS/PES composite membrane was synthesized by coating amphiphilic polymer HEMA-PDMS,which was obtained from copolymerization of hydrophilic hydroxyethyl methacrylate(HEMA)and hydrophobic polydimethylsiloxane(PDMS),onto the surface of microporous polyethersulfone(PES)substrate membrane,which was fabricated by phase inversion using polyethylene glycol(PEG)for pore formation.The HEMA-PDMS/PES composite membranes were characterized via SEM,FTIR,water contact angle measuring instrument and TGA.The CO_(2) and O_(2) permeability as well as the hemolytic performance of the HEMA-PDMS/PES composite membranes were evaluated via gas permeability experiments and hemolysis rate analysis.The effects of adsorption temperature,adsorption time,and mass concentration of bovine serum albumin(BSA)on the BSA adsorption performance of the composite membrane were analyzed,while the adsorption kinetics and thermodynamic processes were explored.The results indicated that the HEMA-PDMS/PES composite membranes showed dense and defect-free surface,with no mass loss before 400℃,and a surface water contact angle of approximately 40°.Meanwhile,the HEMA-PDMS/PES composite membranes exhibited CO_(2)/O_(2) selectivity of 6.53 and low hemolysis rate(0.207%~0.434%).Compared with that of the unmodified PDMS/PES composite membrane,the maximum BSA adsorption capacity of the HEMA-PDMS/PES composite membrane was reduced by up to 13.494%.The adsorption isotherm of the HEMA-PDMS/PES composite membrane conformed to the Langmuir adsorption model and pseudo-second-order kinetics adsorption.The BSA adsorption process was chemical adsorption,which was attributed to the hydrogen bonds formed among the polar groups of BSA and HEMA causing BSA to adsorb on the membrane surface.
作者
张芮萌
于奕菲
陈星宇
武俊良
张心芦
张秀娟
ZHANG Ruimeng;YU Yifei;CHEN Xingyu;WU Junliang;ZHANG Xinlu;ZHANG Xiujuan(State Key Laboratory of Fine Chemicals,School of Chemical Engineering,Ocean and Life Science,Dalian University of Technology,Panjin 124221,Liaoning,China;Leicester International Institute,Dalian University of Technology,Panjin 124221,Liaoning,China;R&D Center of Membrane Science and Technology,Dalian University of Technology,Dalian 116024,Liaoning,China)
出处
《精细化工》
北大核心
2025年第8期1779-1786,共8页
Fine Chemicals
基金
辽宁省自然科学基金项目(2023-MS-114)。
关键词
甲基丙烯酸羟乙酯
聚二甲基硅氧烷
蛋白吸附
亲水改性
化学吸附
生物工程
hydroxyethyl methacrylate
polydimethylsiloxane
protein adsorption
hydrophilic modification
chemisorption
biological engineering
