摘要
Intermittent fasting(IF)is increasingly recognized as an effective dietary intervention for slowing aging process and alleviating metabolic disturbances in multiple chronic diseases,especially in cardiovascular diseases(CVDs).Despite recent progress,the mechanisms behind its effects on cardiovascular health from the perspective of circadian rhythms are not yet fully understood.This review aims to explore the interaction between IF and circadian rhythms,focusing on their combined effects on cardiometabolic risks and cardiovascular outcomes.Evidence from animal models and clinical trials suggests that IF provides protective effects against cardiac damage and dysfunction.It is also indicated that IF influences key cardiometabolic risk factors,such as insulin sensitivity,inflammation,and lipid metabolism,by aligning with the intrinsic biological rhythms.Additionally,we discuss the therapeutic potential of IF in cardiovascular outcomes,particularly in individuals with circadian disruptions.This review also highlights future research directions to identify the most effective fasting protocols and assess the long-term cardiovascular benefits of IF in disease prevention and treatment.
基金
supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0503204)
the National Natural Science Foundation of China(82421001,823B2005,824B1015,82230014,81930007,and 32100426)
the National Key Research and Development Program of China(2021YFC2502300 and 2022YFE0103500)
the National Science Fund for Distinguished Young Scholars(81625002)
the Shanghai Municipal Health Commission(2022JC013,2023ZZ02021,GWVI-11.1-26,and 2022ZZ01008)
the Science and Technology Commission of Shanghai Municipality(22JC1402100,22DZ2292400,and 20YF1426100)
the Shanghai Municipal Education Commission(SHSMU-ZDCX20210700)
the Shanghai Institutions of Higher Learning,the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMUZDCX20210700)(Project 2021-01-07-00-02-E00083)
the National High Level Hospital Clinical Research Funding(2022-PUMCH-C023)
the Medical-Engineering Joint Funds of Shanghai Jiao Tong University(YG2022QN107)
the Pudong New District Health Commission(PW2023E-02).
