摘要
消化道肿瘤发病率逐年上升,已经成为发生率高和预后差的世界性健康问题。铁死亡作为一种新型的死亡方式,其主要是由细胞内铁代谢异常引起细胞内铁过量,导致细胞内活性氧(reactive oxygen species, ROS)的大量产生和脂质过氧化物的积累。随着铁死亡的研究逐渐深入,发现铁死亡可以增强消化道肿瘤细胞对药物治疗的敏感性,从而达到比较好的治疗效果,因此,近些年来这种死亡方式在消化道肿瘤的治疗领域引起了广泛的关注。传统中药具有悠久的使用历史,由于其成本较低,不良反应少的特点,已经广泛应用于癌症的治疗,越来越多的研究发现,传统中药能够诱导消化道肿瘤发生铁死亡,从而抑制肿瘤细胞的生长和转移。该文主要通过介绍铁死亡机制,进一步引出中药单体通过调控铁代谢、抑制与铁死亡相关的抗氧化系统、调控核因子E2相关因子2 (nuclear factor erythroid 2-related factor 2,NRF2)三个方面诱导消化道肿瘤细胞发生铁死亡,从而达到抑制消化道肿瘤的发生与发展,并且对传统中药以及中药单体与化疗药物联用抗消化道肿瘤的研究进行了部分阐述,为消化道肿瘤的治疗提供了新思路。
The incidence of gastrointestinal tumors is increasing year by year and it has become a worldwide health problem with high incidence and poor prognosis.Ferroptosis,a new type of cell death,is mainly caused by abnormal intracellular iron metabolism leading to excess iron,which results in high production of intracellular reactive oxygen species(ROS)and accumulation of lipid peroxides.With the gradual deepening of the study of ferroptosis,it is found that ferroptosis can sensitize gastrointestinal tumor cells to drug therapy,so as to achieve a better therapeutic effect.Therefore,ferroptosis has attracted widespread attention in the field of treatment of gastrointestinal tumors in recent years.Traditional Chinese medicines have a long history and have been widely utilized in the treatment of cancer due to its low cost and fewer adverse effects.More and more studies have found that traditional Chinese medicine can induce ferroptosis in gastrointestinal tumors and thus inhibit tumor cell growth and metastasis.Here we first introduce the theory of ferroptosis,then further present traditional Chinese medicine monomers that induce ferroptosis in gastrointestinal tumor cells through modulating iron metabolism,inhibiting ferroptosis related antioxidant system and regulating nuclear factor erythroid 2-related factor 2(NRF2),thereby inhibiting gastrointestinal tumorigenesis and progression.Moreover,we expound the research of anti-gastrointestinal tumor using traditional Chinese medicine and traditional Chinese medicine monomer combined with chemotherapy drugs to provide a new way of thinking for the treatment of digestive tract tumors.
作者
沈莹雪
贾彦彬
SHEN Ying-Xue;JIA Yan-Bin(Department of Pathogenic Microbiology,School of Basic Medicine and Forensic Medicine,Bao Tou Medical College,Baotou 014040,Inner Mongolia,China)
出处
《中国生物化学与分子生物学报》
北大核心
2025年第6期853-861,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
内蒙古自然科学基金(No.2024MS08079)
包头医学院创新团队(No.bycxtd-06)和包头医学院科学研究基金项目(No.BYJJ-GDJY202313)资助。
关键词
消化道肿瘤
铁死亡
传统中药
中药单体
gastrointestinal stromal tumors(GIST)
ferroptosis
traditional Chinese medicine
Chinese medicine monomer
