摘要
Atrial fibrillation(AF)is the most common sustained arrhythmia worldwide and is associated with poor clinical outcomes and a huge economic burden on healthcare systems.Optimized anticoagulation,better symptom control via rhythm or rate control,and comprehensive comorbidity/risk factor management are 3 essential pillars of current AF management,where much progress has been made during the past decades.However,numerous challenges in AF management remain at the disease,patient,and population levels,including an incomplete understanding of basic mechanisms that can be clinically targeted;heterogenous progressive natural history;poor correlation between rhythm and symptoms/outcomes;as well as suboptimal detection methods and treatment options.Recent advances in disease perception in combination with modern monitoring devices,state-of-the art computational models,and novel antiarrhythmic drugs and ablation strategies can contribute to addressing these issues,ultimately leading to a paradigm shift in AF diagnosis,classification,and treatment.This narrative review summarizes these key challenges and future opportunities in the field of AF management.
基金
supported by the Netherlands Organization for Scientific Research(NWO/ZonMW Vidi 09150171910029 to J.H.)
the Dutch Heart Foundation(Grant number 01-002-2022-0118,EmbRACE consortium to J.H.)
the CARIM PhD Grant(internal funding of Maastricht University to M.C.)。
