摘要
在哺乳动物胚胎发育早期,卵母细胞来源的mRNA是唯一的基因表达来源,直到合子基因组激活(zygotic genome activation,ZGA)[1].此时,母源mRNA的稳定性和翻译调控对胚胎发育至关重要[2].在众多影响母源mRNA稳定性和翻译效率的因素中,poly(A)尾的长度调控尤为关键[3].已有研究表明,较长的poly(A)尾通常有助于mRNA的稳定性和翻译,而较短的poly(A)尾则会抑制翻译并加速mRNA降解[4].
作者
闫昆明
云昊
程红
YAN KunMing;YUN Hao;CHENG Hong(Key Laboratory of RNA Innovation,Science and Engineering,Shanghai Key Laboratory of Molecular Andrology,Shanghai Institute of Biochemistryand Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China;Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Sciences,Hangzhou Institute for Advanced Study,University ofChinese Academy of Sciences,Hangzhou 310024,China)
出处
《中国科学:生命科学》
北大核心
2025年第7期1519-1522,共4页
Scientia Sinica(Vitae)
