摘要
As a common disease in human life,fungal infection poses a serious threat to human life and health.Moreover,owing to the rapid development of the immune escape mechanisms of fungi and the emergence of new drug-resistant fungi,existing therapeutic drugs are no longer able to meet the treatment needs of patients.In particular,the World Health Organization(WHO)published the first Fungal Priority Pathogens List(FPPL)in 2022,further emphasizing that we need to pay more attention to invasive fungal infections.In addition,the WHO has called for increased global investment in fungal infections and the development of antifungal drugs.In this review,we introduce the mechanism by which innate immune cell PRRs recognize fungal pathogen PAMPs,the role of adaptive immune cells in antifungal immunity,fungal infections caused by immune deficiencies,and the latest research progress in immune-based fungal therapies.
基金
supported by grants from the National Science Fund for Distinguished Young Scholars(82225029 to C.H.W.)
the Key Program of National Natural Science Foundation of China(82430076 to C.H.W.)
the Young Scientists Fund of the National Natural Science Foundation of China(82301989 to R.R.H.,82302628 to Y.Y.D.,82301987 to B.Z.and 82402704 to Y.Y.L.)。
