摘要
目的探究叶酸联合阿托伐他汀对脑梗死合并高同型半胱氨酸(HHcy)患者近期疗效及神经功能的影响。方法选择2021年1月-2023年12月在石城县人民医院接受治疗的脑梗死合并HHcy患者60例为研究对象,按照随机数字表法将其分为对照组和研究组,每组30例。对照组应用阿托伐他汀治疗,研究组应用小剂量叶酸联合阿托伐他汀治疗。比较两组治疗效果、血浆Hcy水平、合并HHcy的情况、认知功能(MoCA评分、NIHSS评分)、不良反应(低血压、恶心呕吐、腹痛)发生率。结果研究组治疗总有效率高于对照组(P<0.05);治疗后7 d、治疗后1个月,研究组血浆Hcy水平均低于对照组(P<0.05);研究组合并HHcy发生率低于对照组(P<0.05);研究组治疗后MoCA评分均高于对照组,而NIHSS评分均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量叶酸联合阿托伐他汀治疗脑梗死合并HHcy患者的近期疗效确切,能够降低患者Hcy水平,减少高Hcy血症发生,改善患者神经功能及认知功能,且安全性较高,值得临床应用。
Objective To investigate the effect of folic acid combined with atorvastatin on short-term efficacy and neurological function in patients with cerebral infarction complicated with high hyperhomocysteinemia(HHcy).Methods A total of 60 patients with cerebral infarction complicated with HHcy who were treated in Shicheng County People's Hospital from January 2021 to December 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 30 patients in each group.The control group was treated with atorvastatin,and the study group was treated with low-dose folic acid combined with atorvastatin.The therapeutic effect,plasma Hcy level,combined HHcy,cognitive function(MoCA score,NIHSS score)and incidence of adverse reactions(hypotension,nausea and vomiting,abdominal pain)were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).At 7 days and 1 month after treatment,the plasma Hcy level in the study group was lower than that in the control group(P<0.05).The incidence of HHcy in the study group was lower than that in the control group(P<0.05).After treatment,the MoCA score of the study group was higher than that of the control group,while the NIHSS score was lower than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-dose folic acid combined with atorvastatin is effective in the treatment of patients with cerebral infarction complicated with HHcy,which can reduce the Hcy level,reduce the occurrence of HHcy,improve the neurological function and cognitive function of patients,and has high safety.It is worthy of clinical application.
作者
廖春群
刘华珍
LIAO Chunqun;LIU Huazhen(Department of Neurology,Shicheng County People's Hospital,Shicheng 342700,Jiangxi,China)
出处
《医学信息》
2025年第16期126-130,共5页
Journal of Medical Information
关键词
叶酸
阿托伐他汀
脑梗死
高同型半胱氨酸
神经功能
Folic acid
Atorvastatin
Cerebral infarction
Hyperhomocysteinemia
Neural function
