摘要
目的探究重复经颅磁刺激对精神分裂症患者认知功能及生活质量的影响。方法选取2022年5月至2024年3月来我院就诊的88例精神分裂症患者作为研究对象,按照随机数字表法将其分为对照组和试验组,每组44例。对照组采用利培酮口崩片治疗,试验组采用重复经颅磁刺激联合利培酮口崩片治疗。比较两组的临床症状、社会功能、认知功能、生活质量、临床疗效及不良反应发生情况。结果治疗后,试验组的阳性和阴性症状量表(PANSS)各分量表(阳性症状、阴性症状、一般病理症状)评分均明显低于对照组(P<0.05)。治疗后,试验组的住院病人观察量表(NOSIE-30)评分明显低于对照组,蒙特利尔认知评估量表(MoCA)评分明显高于对照组(P<0.05)。治疗后,试验组的精神分裂症患者生活质量量表(SQLS)各维度(动力和精力、症状和不良反应、心理社会)评分均明显低于对照组(P<0.05)。试验组的治疗总有效率明显高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论重复经颅磁刺激可改善精神分裂症患者的临床症状、社会功能和认知功能,提高临床疗效及生活质量,且安全性良好。
Objective To explore the effect of repetitive transcranial magnetic stimulation on cognitive function and quality of life in patients with schizophrenia.Methods A total of 88 patients with schizophrenia who came to our hospital from May 2022 to March 2024 were selected as the research objects.The patients were divided into control group and experimental group according to the random number table method,with 44 cases in each group.The control group was treated with risperidone orally disintegrating tablets,and the experimental group was treated with repetitive transcranial magnetic stimulation combined with risperidone orally disintegrating tablets.The clinical symptoms,social function,cognitive function,quality of life,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the scores of Positive and Negative Symptom Scale(PANSS)subscales(positive symptoms,negative symptoms and general pathological symptoms)in the experimental group were significantly lower than those in the control group(P<0.05).After treatment,the 30-item Nurses'Observation Scale for Inpatient Evaluation(NOSIE-30)score of the experimental group was significantly lower than that of the control group,and the Montreal Cognitive Assessment(MoCA)score was significantly higher than that of the control group(P<0.05).After treatment,the scores of each dimension(power and energy,symptoms and adverse reactions and psychology and society)of Schizophrenia Quality of Life Scale(SQLS)in the experimental group were significantly lower than those in the control group(P<0.05).The total effective rate of treatment in the experimental group was significantly higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Repetitive transcranial magnetic stimulation can ameliorate the clinical symptoms,social function and cognitive function of patients with schizophrenia,improve clinical efficacy and quality of life,and has good safety.
作者
李鹏
许婷婷
李康旺
布龙华
游狄乾
LI Peng;XU Tingting;LI Kangwang;BU Longhua;YOU Diqian(Care Department,the Third People's Hospital of Jiangmen,Jiangmen 529000,China)
出处
《临床医学研究与实践》
2025年第23期74-77,共4页
Clinical Research and Practice
关键词
精神分裂症
利培酮
生活质量
临床症状
重复经颅磁刺激
schizophrenia
risperidone
quality of life
clinical symptom
repetitive transcranial magnetic stimulation
