摘要
肿瘤相关抑郁作为肿瘤患者常见并发症,严重影响治疗与预后,但其发病机制尚未完全明确。近年来线粒体能量代谢障碍假说备受关注,而中医认为脾失健运是肿瘤相关抑郁的重要病机,且中医“脾”功能与线粒体特性存在诸多相似。该文从肿瘤细胞线粒体能量代谢障碍角度,深入探讨从脾论治肿瘤相关抑郁的机理,经研究发现,益气健脾、疏肝合脾、化痰醒脾、养血健脾等中医疗法,能有效缓解肿瘤患者抑郁状态,改善线粒体功能,以期为临床肿瘤相关抑郁的治疗提供新的治疗思路和方法。
Tumor-related depression,a common complication in cancer patients,significantly impacts treatment efficacy and prognosis,yet its pathogenesis remains incompletely understood.In recent years,the mitochondrial energy metabolism dysfunction hypothesis has gained attention.Traditional Chinese Medicine(TCM)posits that impaired spleen function is a key pathological mechanism of tumor-related depression,and the characteristics of the TCM“spleen”share similarities with mitochondrial functions.This article explored the mechanism of treating tumor-related depression from the perspective of spleen regulation,focusing on mitochondrial energy metabolism dysfunction in tumor cells.The research indicates that TCM therapies such as tonifying Qi and strengthening spleen,soothing liver and harmonizing spleen,resolving phlegm and awakening spleen,and nourishing blood and fortifying spleen can effectively alleviate depressive symptoms in cancer patients and improve mitochondrial function.The findings aim to provide novel therapeutic strategies for clinical management of tumor-related depression.
作者
黄敏娜
张秋雨
易丹
贾英杰
HUANG Minna;ZHANG Qiuyu;YI Dan;JIA Yingjie(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300382,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300382,China;Tianjin Institute of Traditional Chinese Medicine Oncology,Tianjin 300382,China)
出处
《辽宁中医杂志》
北大核心
2025年第8期209-213,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81603438)
天津市卫生健康委员会中医中西医结合科研项目(2023039)。
关键词
肿瘤相关抑郁
脾
线粒体
能量代谢
从脾论治
tumor-related depression
spleen
mitochondria
energy metabolism
treatment based on spleen regulation
