摘要
目的分析银杏达莫注射液(ginkgo leaf extract and dipyridamole injection,GLED)联合美托洛尔(metopro-lol,Met)治疗冠心病不稳定型心绞痛(unstable angina pectoris,UAP)的效果,以及治疗前后血液流变学的变化。方法目的选取2023年1—12月期间菏泽市牡丹人民医院收治的94例冠心病UAP患者为研究对象,根据治疗方式不同分为两组,对照组47例采用Met治疗,研究组47例在对照组基础上联用GLED治疗。比较两组临床疗效、血液流变学指标、不良反应发生情况。结果研究组总有效率为95.74%(45/47),较对照组的80.85%(38/45)更高,差异有统计学意义(χ^(2)=5.045,P<0.05)。研究组治疗14 d时血液流变学指标均低于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论GLED联合Met治疗冠心病UAP疗效确切,可以改善患者的血液流变学指标。
Objective This study aims to evaluate the therapeutic efficacy of combined Ginkgo biloba extract-dipyridamole injection(GLED)and metoprolol(Met)therapy in unstable angina pectoris(UAP)patients,while system-atically analyzing treatment-associated hemorheological parameter alterations.Methods A total of ninty-four cases of UAP patients with coronary heart disease admitted to Mudan People′s Hospital of Heze City from January to Decem-ber 2023 were purposefully as the study subjects.They were divided into two groups according to different treatment methods.Forty-seven cases in the control group were treated with Met,and forty-seven cases in the study group were treated with GLED on the basis of the control group.The clinical effect,hemorheological indexes and occurrence of ad-verse reactions were compared between the two groups.Results The total effective rate of the study group was 95.74%(45/47),which was higher than 80.85%(38/45)of the control group,and the difference was statistically significant(χ^(2)=5.045,P<0.05).The hemorheology indexes of the study group were lower than those of the control group at 14 days af-ter treatment,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion GLED combined with Met is effective in the treatment of UAP of coronary heart disease,which can improve the hemorheological indexes of patients.
作者
李慧
段李媛
LI Hui;DUAN Liyuan(Internal Medicine Pharmacy,Mudan People′s Hospital of Heze City,Heze 274000,Shandong,China;Department of Cardiology,Mudan People′s Hospital of Heze City,Heze 274000,Shandong,China)
出处
《系统医学》
2025年第12期177-180,共4页
Systems Medicine
关键词
银杏达莫注射液
美托洛尔
冠心病
不稳定型心绞痛
血液流变学
Ginkgo leaf extract and dipyridamole injection
Metoprolol
Coronary heart disease
Unstable angina pectoris
Hemorheology
