摘要
目的:研究通督醒脑针刺法治疗缺血性脑卒中后轻度认知障碍(PISMCI)的临床疗效。方法:将70例PISMCI患者随机分为对照组和观察组,每组35例(每组各脱落1例)。两组患者给予常规治疗、认知训练及口服盐酸多奈哌齐片,观察组加用通督醒脑针刺法,疗程均为4周,比较两组患者治疗前后蒙特利尔认知评估量表(MoCA)、简易智力状态检查量表(MMSE)、日常生活能力评分(ADL)、VILIP-1、NFL、Hcy、IL-6、血液流变学水平(红细胞压积、血浆黏度、全血黏度、纤维蛋白原)的变化、评估两组患者治疗后的疗效,记录不良反应情况。结果:两组患者治疗后MoCA、MMSE、ADL评分均较治疗前升高(P<0.05),观察组治疗后MoCA、MMSE、ADL评分均高于对照组(P<0.05);两组患者治疗后VILIP-1、NFL、Hcy、IL-6、血液流变水平均较治疗前下降(P<0.05),观察组治疗后的VILIP-1、NFL、Hcy、IL-6、血液流变学水平均低于对照组(P<0.05);观察组总有效率(91.18%)高于对照组(79.41%),差异具有统计学意义(P<0.05),在研究过程中,两组均未发现不良反应。结论:通督醒脑针刺法可有效改善认知功能,提高患者日常生活能力,促进神经功能恢复,其机制可能与下调体内血清标志物表达、改善炎性指标水平有关。
Objective:To study the clinical efficacy of Tongdu Xingnao Acupuncture in the treatment of patients with mild cognitive impairment after ischaemic stroke(PISMCI).Methods:Seventy patients with PISMCI were randomly divided into a control group and an observation group,with 35 patients in each group(1 patient in each group).The two groups were given conventional treatment,cognitive training,and oral donepezil hydrochloride tablets,while the observation group was given the Tongdu Xingnao Acupuncture method for 4 weeks,and the Montreal Cognitive Assessment Scale(MoCA),the Mental State Examination(MMSE),the Ability of Daily Living(ADL)score,VILIP-1,NFL,Hcy,IL-6,blood rheology levels(erythrocyte pressure volume,plasma viscosity,whole blood viscosity,IL-6,and so on)before and after the treatment.The changes of Montreal cognitive assessment scale(MoCA),simple mental status examination scale(MMSE),ability to perform activities of daily living(ADL),VILIP-1,NFL,Hcy,IL-6,and blood rheological levels(erythrocyte pressure volume,plasma viscosity,whole blood viscosity,fibrinogen)were compared between the two groups before and after treatment,and the therapeutic efficacies were evaluated,and the adverse reactions were recorded.Results:The MoCA,MMSE and ADL scores of the two groups were higher than before treatment(P<0.05),and the MoCA,MMSE and ADL scores of the observation group were higher than those of the control group after treatment(P<0.05);the VILIP-1,NFL,Hcy,IL-6,and haematological rheology levels of the two groups were lower than those of the pre-treatment period(P<0.05),and the observation group s VILIP-1,NFL,Hcy,IL-6,and blood rheology levels after treatment were lower than those of the control group(P<0.05);the total effective rate of the observation group(91.18%)was higher than that of the control group(79.41%)(P<0.05),and throughout the course of the study,no adverse reactions were detected in the 2 groups.Conclusion:Tongdu Xingnao Acupuncture can effectively improve cognitive function,enhance the ability of daily life,and promote the recovery of neurological function,and its mechanism may be related to the down-regulation of the expression of serum markers in vivo and the improvement of the level of inflammatory indicators.
作者
张茜
武扬
赵保东
张捷
张晓霞
Zhang Xi;Wu Yang;Zhao Baodong;Zhang Jie;Zhang Xiaoxia(The First Clinical College,Shanxi University of Chinese Medicine,Taiyuan 030024,China;Department of Rehabilitation Medicine,Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan 030012,China;Taiyuan Emergency Medical Service Centre,Taiyuan 030009,China)
出处
《亚太传统医药》
2025年第8期68-72,共5页
Asia-Pacific Traditional Medicine
基金
山西中医药大学研究生实践项目(X2024SJ013)
山西省中医药创新团队项目(zyytd2024005)
山西省中医药管理局项目(2024ZYY2B007)。
