摘要
Objective:To observe the impact of Yi Jin Jing(Sinew-transforming Exercise)plus individualized exercise prescription combining treadmill training and strength training on geriatric female patients with primary osteoporosis(POP).Methods:Seventy-five geriatric female POP patients were recruited and randomized into a control group,an exercise therapy group,or a combined group,with 25 cases in each group.The control group received regular treatment,including health education and oral administration of calcium carbonate and vitamin D3 granules and alendronate sodium.The exercise therapy group received treadmill-based exercise and strength training 3 times weekly in addition to the intervention given to the control group.The combined group underwent treadmill-based exercise,strength training,and Yi Jin Jing training 3 times weekly in addition to the intervention given to the control group.The intervention lasted 24 weeks in each group.Before and after treatment,the visual analog scale(VAS)score,grip strength,bone density of L1-L4 and femoral neck,and serum levels of parathyroid hormone(PTH),25-hydroxyvitamin D3[25(OH)D3],osteocalcin(OC),procollagenⅠN-terminal propeptide(PINP),and beta C-telopeptide of typeⅠcollagen(β-CTX)were compared.Results:After treatment,the combined group and exercise therapy group showed a significant decrease in the VAS score and an increase in the grip strength(P<0.05).The bone density of L1-L4 and femoral head rose in all three groups after the intervention(P<0.05),together with markedly decreased serum PTH,OC,PINP,andβ-CTX levels(P<0.05)and a notably increased 25(OH)D3 level(P<0.05).After treatment,the combined and exercise therapy groups had a significantly lower VAS score and higher grip strength(P<0.05)compared to the control group;the former two groups also had a higher bone density of L1-L4 and femoral head(P<0.05),lower serum PTH,PINP,andβ-CTX levels(P<0.05)and a higher 25(OH)D3 level(P<0.05).Compared to the exercise therapy group,the combined group had a lower VAS score,higher L1-L4 and femoral head bone density,and lower serum PINP andβ-CTX levels.Conclusion:Based on regular treatment,personalized exercise prescriptions centered on Yi Jin Jing can alleviate pain,enhance grip strength and bone density,and correct abnormal expression of bone metabolism markers in geriatric females with POP.
目的:观察易筋经联合跑台运动和力量训练的个性化运动处方对老年女性原发性骨质疏松症(POP)患者的影响。方法:选择75例老年女性POP患者,随机分为对照组、运动训练组和联合组,每组25例。对照组接受常规治疗,包括健康宣教及口服碳酸钙D3颗粒和阿仑膦酸钠;运动训练组在对照组的基础上进行跑台和力量训练,3次/周;联合组在对照组的基础上接受跑台训练、力量训练和易筋经训练,3次/周。三组患者均干预24周。比较干预前后视觉模拟量表(VAS)、握力、腰椎L1-L4和股骨颈骨密度以及血清甲状旁腺激素(PTH)、25-羟基维生素D3[25(OH)D3]、骨钙素(OC)、Ⅰ型原胶原N-端前肽(PINP)和β-Ⅰ型胶原C-末端肽(β-CTX)的变化。结果:与本组干预前相比,干预后联合组和运动训练组VAS评分明显降低,握力增加(P<0.05)。三组患者干预后L1-L4和股骨颈骨密度明显增加(P<0.05),血清PTH、OC、PINP和β-CTX水平显著减低(P<0.05),25(OH)D3水平明显升高(P<0.05)。干预后,与对照组相比,联合组和运动训练组VAS评分显著降低(P<0.05),握力增加(P<0.05);腰椎L1-L4和股骨颈骨密度显著提高(P<0.05);血清PTH、PINP和β-CTX明显降低(P<0.05),而25(OH)D3水平显著增高(P<0.05)。与运动训练组比较,联合组VAS评分更低,L1-L4和股骨颈骨密度更高,血清PINP和β-CTX水平更低。结论:基于常规治疗,易筋经为主的个性化运动处方有助于缓解老年女性POP患者的疼痛,提高其握力和骨密度,改善骨代谢标志物的异常表达。
基金
贵州省卫生健康委科学技术基金项目,No.gzwkj2022-306.
