摘要
目的探讨津力达颗粒联合利拉鲁肽治疗初诊2型糖尿病(T2DM)患者疗效及其对胰岛功能、氧化应激水平的影响。方法选取2020年1月—2023年12月邢台医学院附属医院内分泌科收治的初诊T2DM患者120例,依据随机数字表法分为对照组和研究组,每组均60例。对照组给予利拉鲁肽治疗,研究组给予津力达颗粒联合利拉鲁肽治疗,2组均连续治疗12周。比较2组T2DM患者疗效,分析患者血糖指标[空腹血糖(FPG)、餐后2小时血糖(2 h PG)、糖化血红蛋白(HbA 1c)]、胰岛功能[胰岛β细胞功能指数(HOMA-β)、胰岛素敏感指数(HOMA-IS)、胰岛素抵抗指数(HOMA-IR)]及氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)]水平变化与不良反应。结果研究组总有效率优于对照组(91.67%vs.78.33%,χ^(2)=4.183,P=0.041)。治疗12周后,2组FPG、2 h PG、HbA 1c均低于治疗前,且研究组低于对照组(t/P=4.372/<0.001、2.646/0.009、4.540/<0.001)。治疗12周后,2组HOMA-β、HOMA-IS均较治疗前升高,HOMA-IR较治疗前降低,且研究组HOMA-β、HOMA-IS水平高于对照组,HOMA-IR低于对照组(t/P=25.323/<0.001、2.387/0.019、2.419/0.017)。治疗8周、12周后,2组SOD、GSH-PX均较治疗前及治疗4周后升高,MDA降低,且研究组SOD、GSH-PX高于对照组,MDA低于对照组(治疗8周:t/P=3.719/<0.001、3.347/0.001、2.305/0.023;治疗12周:t/P=8.701/<0.001、5.309/<0.001、8.461/<0.001)。研究组总不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论津力达颗粒联合利拉鲁肽治疗T2DM患者可以提高临床疗效,改善胰岛功能,同时降低氧化应激水平。
Objective To investigate the effect of Jinlida Granules combined with liraglutide in the treatment of newly diagnosed type 2 diabetes mellitus(T2DM)and its influence on islet function and oxidative stress level.Methods From January 2020 to December 2023,120 newly diagnosed T2DM patients in the Department of endocrinology of Xingtai Central Hospital were selected,and they received conventional medication,diet and exercise therapy in the hospital.According to the random number table method,they were divided into control group and study group,with 60 cases in each group.The control group was treated with liraglutide,and the study group was treated with Jinlida Granules Combined with liraglutide.Both groups were treated for 12 weeks.The curative effects of two groups of T2DM patients were compared,and the changes of blood glucose indexes[fasting blood glucose(FBG),2-hour postprandial blood glucose(2-hour PBG),glycosylated hemoglobin(HbA 1c)],islet function[isletβcell function index(HOMA-β),insulin sensitivity index(homa-is),insulin resistance index(HOMA-IR)]and oxidative stress[malondialdehyde(MDA),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)]levels and adverse reactions were analyzed.Results The total effective rate of the study group was better than that of the control group[91.67%vs 78.33%,χ^(2)=4.183,P=0.041].After 12 weeks of treatment,FBG,2h FBG and HbA 1c in the two groups were lower than before treatment,and the study group was lower than the control group(t/P=4.372/<0.001,2.646/0.009,4.540/<0.001).After 12 weeks of treatment,the levels of HOMA-βand homa-is in the two groups were higher than those before treatment,and HOMA-IR in the study group was lower than that in the control group(t/P=25.323/<0.001,2.387/0.019,2.419/0.017).After 8 and 12 weeks of treatment,SOD and GSH-Px in the two groups were higher than those before treatment and after 4 weeks of treatment,and MDA in the study group was lower than that in the control group(t/P=3.719/<0.001,3.347/0.001,2.305/0.023 at 8 weeks of treatment;t/P=8.701/<0.001,5.309/<0.001,8.461/<0.001 at 12 weeks of treatment).During the 12-week treatment period,different types of adverse reactions occurred in both groups.There was no significant difference in the total incidence of adverse reactions between the study group and the control group(P>0.05).Conclusion The combination of traditional Chinese and Western medicine and the use of Jinlida granules combined with Liraglutide can improve the clinical efficacy of T2DM patients,improve pancreatic function,and reduce oxidative stress levels.
作者
王宪娟
何昆
李静
赵丽娟
李正川
彭兆康
吉淑敏
Wang Xianjuan;He Kun;Li Jing;Zhao Lijuan;Li Zhengchuan;Peng Zhaokang;Ji Shumin(Department of Endocrinology,Xingtai Central Hospital,Hebei,Xingtai 054000,China)
出处
《疑难病杂志》
2025年第8期954-958,共5页
Chinese Journal of Difficult and Complicated Cases
基金
2024年度河北省中医药类科学研究课题计划项目(2024520)。
关键词
2型糖尿病
津力达颗粒
利拉鲁肽
临床疗效
血糖指标
氧化应激
Type 2 diabetes
Jinlida Granules
Liraglutide
Therapeutic effect
Blood glucose index
Oxidative stress
