摘要
目的:探讨血清三羧酸(TCA)循环代谢物与老年人代谢综合征(MetS)的相关性。方法:本研究为横断面研究,选取2016年6月至9月在安徽省六安市收集的1020名年龄≥60周岁老年人的问卷调查和体格检查数据,并利用气相色谱-串联质谱法检测血清中TCA循环代谢物水平。根据MetS诊断标准将数据进行分组,采用卡方检验、Mann-Whitney U检验和二元Logistic回归模型探讨TCA循环代谢物与MetS之间的关系。结果:在血清TCA靶标代谢物中,有6个代谢物水平在MetS组与非MetS组中的差异具有统计学意义(P<0.05)。与低分位组相比,高分位组的异柠檬酸(OR=0.581,95%CI 0.418~0.809)、α-酮戊二酸(OR=0.565,95%CI 0.410~0.778)、延胡索酸(OR=0.684,95%CI 0.479~0.976)和苹果酸(OR=0.635,95%CI 0.461~0.874)分别是MetS风险保护因素;而高分位组的柠檬酸/异柠檬酸比值(OR=1.740,95%CI 1.250~2.423)和琥珀酸/异柠檬酸比值(OR=1.868,95%CI 1.342~2.600)是MetS危险因素。结论:高水平的异柠檬酸、α-酮戊二酸、延胡索酸和苹果酸与老年人MetS发生风险降低相关;而高水平的柠檬酸/异柠檬酸和琥珀酸/异柠檬酸比值与老年人MetS发生风险升高相关。
Objective:To investigate the correlations between serum tricarboxylic acid(TCA)cycle metabolites and metabolic syndrome(MetS)in the elderly.Methods:This was a cross-sectional study,data were collected from questionnaires and physical examinations of 1020 older adults aged≥60 years conducted in Lu an City,Anhui Province,from June to September 2016.Using gas chromatography-tandem mass spectrometry to detect TCA cycle metabolite levels in serum.Then participants were grouped according to the diagnostic criteria for MetS.Chi-square test,Mann-Whitney U test,and binary logistic regression models were used to investigate the association between TCA cycle metabolites and MetS.Results:Six targeted TCA cycle metabolite indicators showed statistically significant differences between the MetS and non-MetS groups(P<0.05).Compared with the low-quartile group,the high quartile groups of isocitrate(OR=0.581,95%CI 0.418-0.809),α-ketoglutarate(OR=0.565,95%CI 0.410-0.778),fumarate(OR=0.684,95%CI 0.479-0.976),and malate(OR=0.635,95%CI 0.461-0.874)were protective factors for MetS risk.However,the citrate/isocitrate ratio(OR=1.740,95%CI 1.250-2.423)and succinate/isocitrate ratio(OR=1.868,95%CI 1.342-2.600)in the high tertile groups were risk factors for MetS.Conclusion:High levels of isocitrate,α-ketoglutarate,fumarate,and malate were associated with a reduced risk of MetS in the elderly,whereas high levels of citrate/isocitrate and succinate/isocitrate ratios were associated with an elevated risk of MetS.
作者
马志会
刘开永
MA Zhihui;LIU Kaiyong(School of Public Health,Anhui Medical University,Hefei 230032,China)
出处
《现代医学》
2025年第7期1115-1120,共6页
Modern Medical Journal
基金
国家自然科学基金(82073558)。
关键词
代谢综合征
三羧酸循环
代谢物
老年人
metabolic syndrome
tricarboxylic acid cycle
metabolites
the elderly
