摘要
细胞因子风暴是重症感染患者中常见且致命的病理过程,其核心机制在于免疫系统过度激活导致的细胞因子大量释放,进而引发急性炎症反应和多器官功能衰竭。研究细胞因子风暴的机制和治疗方法对于提高重症感染患者的生存率具有重要意义。本文系统阐述了重症感染中细胞因子风暴的发病机制、病理特征以及当前的诊疗进展,探讨抗炎药物、免疫调节治疗以及支持性治疗等多种治疗策略,并总结近年来在细胞因子风暴治疗方面的新兴药物和方法的临床试验数据,旨在为实现细胞因子风暴的精准诊断和治疗提供理论支持和实践指导,为重症感染患者的临床治疗提供的参考依据。
Cytokine storm is a common and fatal pathological process in patients with severe infections.Its core mechanism involves the excessive activation of the immune system,leading to a massive release of cytokines,which in turn causes acute inflammatory responses and multiple organ failure.Studying the mechanisms and treatment methods of cytokine storm is of great significance for improving the survival rate of patients with severe infections.This paper systematically elucidates the pathogenesis,pathological characteristics,and current progress in the treatment of cytokine storm in severe infections,discusses the treatment strategies such as anti-inflammatory drugs,immunomodulatory therapy,and supportive care,and summarizes the results of clinical trials of emerging drugs and methods for treating cytokine storm,hoping to provide theoretical evidence and practical guidance for the precise diagnosis and treatment of cytokine storm and provide reference for clinical treatment of patients with severe infections.
作者
邹海
Zou Hai(Institute of Emergency and Disaster Medicine,Tianjin University,Tianjin 300072,China Intensive Care Unit,Fudan University Shanghai Cancer Center;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)
出处
《中华微生物学和免疫学杂志》
北大核心
2025年第7期611-618,共8页
Chinese Journal of Microbiology and Immunology
关键词
重症感染
细胞因子风暴
诊断
治疗
Severe infection
Cytokine storm
Diagnosis
Treatment
