摘要
围术期疼痛、急性疼痛、慢性疼痛等都会对患者身体机能造成影响,有时甚至会诱发应激反应,而艾司氯胺酮能够通过阻断N-甲基-D-天冬氨酸受体达到精神疾病治疗与降低疼痛中枢敏化的作用,因而逐渐被应用于围术期麻醉以及多场景疼痛管理与治疗中。本文将对艾司氯胺酮的疼痛治疗研究进展进行综述,详细分析其止痛作用机制,论述药物应用于围术期麻醉、疼痛治疗中的作用,最后分析药物不良反应,提出合理应用与未来研究的相关建议。
Perioperative pain,acute pain,chronic pain,etc.can affect the patient's physical function,and sometimes even induce stress response.Esketamine can achieve the treatment of mental illness and reduce pain central sensitization by blocking N-methyl-D-aspartate receptor,so it is gradually applied to perioperative anesthesia and multiscene pain management and treatment.This article will review the research progress of pain treatment with esketamine,analyze its analgesic mechanism in detail,discuss the role of drugs in perioperative anesthesia and pain treatment,and finally analyze adverse drug reactions,and put forward relevant suggestions for rational application and future research.
作者
向文青
思永玉
XIANG Wenqing;SI Yongyu(Department of Anesthesiology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan,China)
出处
《系统医学》
2025年第14期186-189,共4页
Systems Medicine
关键词
艾司氯胺酮
疼痛治疗
围术期
疼痛管理
研究进展
Esketamine
Pain treatment
Perioperative period
Pain management
Research progress
