摘要
目的制备地氯雷他定药物共晶,为其性质研究提供基础。方法以地氯雷他定为原料,2,4-二羟基苯甲酸为前驱体,采用溶剂挥发法,制备得到地氯雷他定共晶。应用^(1)H NMR、^(13)C NMR、粉末X射线衍射、差示扫描量热法、热重法等对制备得到的共晶进行表征。结果共晶各表征图谱均不同于地氯雷他定及2,4-二羟基苯甲酸。结论地氯雷他定与2,4-二羟基苯甲酸成功形成共晶。
Objective To prepare desloratadine co-crystal to provide a basis for its property research.Methods Using desloratadine as starting material and 2,4-dihydroxybenzoic acid as eutectic precursor,the co-crystal was obtained by solvent volatilization.The structure of the co-crystal was characterized by ^(1)H NMR,^(13)C NMR,power X-ray diffraction,differential scanning calorimetry and thermal gravimetric analysis.Results The characteristic spectra of the co-crystal differed from those of desloratadine and 2,4-dihydroxybenzoic acid.Conclusion Desloratadine and 2,4-dihydroxybenzoic acid successfully form a co-crystal.
作者
孙慧慧
吴丽莎
沙莎
刘桂永
颜世强
SUN Hui-hui;WU Li-sha;SHA Sha;LIU Gui-yong;YAN Shi-qiang(Shandong Dyne Marine Biopharmaceutical Co.,Ltd.,Weihai 264300,China;Weihai Ocean Vocational College,Weihai 264300,China)
出处
《食品与药品》
2025年第4期354-357,共4页
Food and Drug
基金
山东省自然科学基金重点项目(编号:ZR2020KH002)。
关键词
地氯雷他定
共晶
制备
表征
desloratadine
co-crystal
preparation
characterization
