摘要
背景:患有代谢综合征的个体发生慢性疾病的风险增加,尤其是2型糖尿病、非酒精性脂肪肝病及心血管疾病。而溶酶体与多种代谢性疾病存在联系,但具体的作用尚未完全阐明。目的:通过文献检索探究溶酶体在代谢综合征的研究进展,为阐明溶酶体及溶酶体酶在代谢综合征中的作用机制提供思路。方法:第一作者于2024年10月应用计算机检索PubMed、Web of Science数据库建库至2024年10月发表的相关文献,以“metabolic syndrome,glucose metabolism,lipid metabolism,type 2 diabetes mellitus,non-alcoholic fatty liver disease,lysosomes,lysosomal enzymes”为英文检索词,最终纳入90篇文献进行汇总分析。结果与结论:①代谢紊乱与代谢综合征及其他与代谢相关的疾病有关,代谢紊乱包括葡萄糖代谢紊乱和脂质代谢紊乱,葡萄糖代谢受到干扰后易引发糖尿病的发生,可能导致严重并发症和促成代谢综合征的发生;脂质代谢异常可能会造成血脂异常和脂肪肝疾病;②溶酶体酶在代谢中发挥了重要作用,其功能障碍导致多种代谢紊乱;③溶酶体酶中几种组织蛋白酶的异常与胰岛素抵抗有关并进一步引发2型糖尿病;④溶酶体酸性脂肪酶活性缺陷是导致非酒精性脂肪肝病发展的触发因素之一。
BACKGROUND:Individuals with metabolic syndrome are at increased risk of developing chronic diseases,particularly type 2 diabetes mellitus,non-alcoholic fatty liver disease,and cardiovascular diseases.Lysosomes are linked to various metabolic disorders,but their specific roles have not been fully elucidated.OBJECTIVE:To explore the research progress on lysosomes in metabolic syndrome through a literature search,providing insights into the mechanisms by which lysosomes and their enzymes influence metabolic syndrome.METHODS:The first author conducted a computerized search of PubMed and Web of Science from database inception to October 2024 using the keywords of“metabolic syndrome,glucose metabolism,lipid metabolism,type 2 diabetes mellitus,non-alcoholic fatty liver disease,lysosomes,lysosomal enzymes.”A total of 90 relevant articles were identified and analyzed.RESULTS AND CONCLUSION:(1)Metabolic disturbances are associated with metabolic syndrome and other metabolism-related diseases.These disturbances include glucose and lipid metabolism disorders.Disrupted glucose metabolism can lead to diabetes,causing severe complications and contributing to the development of metabolic syndrome.Abnormal lipid metabolism may result in dyslipidemia and fatty liver disease.(2)Lysosomal enzymes play a crucial role in metabolism,and their dysfunction can lead to various metabolic disorders.(3)Abnormalities in several lysosomal cathepsins are linked to insulin resistance,further contributing to the development of type 2 diabetes.(4)Deficiency in lysosomal acid lipase activity is one of the triggers for the progression of non-alcoholic fatty liver disease.
作者
邹瑜茜
陈燕燕
蒋鹏
陈婷
丁伶伶
Zou Yuxi;Chen Yanyan;Jiang Peng;Chen Ting;Ding Lingling(Department of Physiology,Medical School of Jiangsu University,Zhenjiang 212013,Jiangsu Province,China;Department of Pharmacology,Medical School of Jiangsu University,Zhenjiang 212013,Jiangsu Province,China)
出处
《中国组织工程研究》
北大核心
2026年第11期2823-2833,共11页
Chinese Journal of Tissue Engineering Research
基金
中国博士后面上项目(2023M741425),项目负责人:丁伶伶
江苏省高校自然科学基金项目(24KJB320001),项目负责人:陈燕燕
江苏省研究生科研与实践创新计划项目(KYCX25_4289),项目负责人:邹瑜茜。
关键词
代谢综合征
代谢紊乱
葡萄糖代谢紊乱
脂质代谢紊乱
溶酶体
溶酶体酶
2型糖尿病
非酒精性脂肪肝病
metabolic syndrome
metabolic disturbances
glucose metabolism disorder
lipid metabolism disorder
lysosome
lysosomal enzymes
type 2 diabetes
non-alcoholic fatty liver disease
