摘要
环境有害因素导致的生殖损伤是生育力下降的重要原因,也是目前全球性重大公共卫生问题。阐明环境有害因素暴露与生殖系统损伤的因果关系、揭示其分子作用机制、构建精准生殖损伤评估与防治体系对于维护人口生殖健康具有重要意义。本综述简要概述了近3年环境新污染物、重要的物理有害因素和生物因素致生殖损伤的研究进展,总结了新的替代模型、暴露组学及人工智能等新技术在本领域中的应用,并对环境有害因素生殖健康评估、预防与干预等潜在研究方向进行了初步探讨。
Environmentally-induced reproductive toxicity is one of the important causes of fertility declines and has become a significant global public health challenge.Elucidating the causal links between exposure to environmental hazards and reproductive damage,unraveling the underlying molecular mechanisms,and establishing precise reproductive injury assessment systems are crucial for development of targeted interventions and safeguarding human reproductive health.In this article,we systematically review the research progress on reproductive toxicity caused by emerging environmental chemical pollutants,common physical factors,and biological factors in the recent 3 years.We summarize the new technologies in the field of toxicology,including novel experimental models,exposomics,and artificial intelligence.We also discuss the potential research directions in risk assessment,prevention and intervention of environmental factors-induced reproductive damage.
作者
刘晋祎
张文峰
LIU Jinyi;ZHANG Wenfeng(Department of Military Toxicology,Faculty of Military Preventive Medicine,Army Medical University(Third Military Medical University),Chongqing,China)
出处
《陆军军医大学学报》
北大核心
2025年第15期1685-1694,共10页
Journal of Army Medical University
基金
国家自然科学基金面上项目(82173555,82473675)
国家自然科学基金重点项目(82130097)。
关键词
环境有害因素
生殖损伤
新技术方法
environmental hazards
reproductive damage
new technologies
