摘要
认知障碍是以记忆、思维、判断等高级认知功能进行性减退为特征的临床综合征,其病因病机复杂,尚缺乏特效药物干预。二甲双胍作为2型糖尿病的一线降糖药物,除可降低血糖外,其还可改善认知障碍。研究显示,二甲双胍干预CI的作用机制主要包括调节β淀粉样蛋白与tau蛋白代谢、降低胰岛素抵抗、抑制神经炎症、提高突触可塑性、改善线粒体功能障碍、调节肠道菌群及脂质代谢等。未来研究需通过多学科交叉协作,充分整合多组学数据,结合先进技术进一步揭示其效应机制。
Cognitive impairment(CI)is a clinical syndrome characterized by progressive decline in advanced cognitive functions such as memory,thinking,and judgment.Its etiology and pathogenesis are complex,and there is currently a lack of specific drug interventions.Metformin,as a first-line hypoglycemic drug for type 2 diabetes,not only lowers blood glucose levels but also improves CI.This article reviews and summarizes the pharmacological effects and mechanisms of metformin in improving Alzheimer’s disease,diabetes cognitive impairment,cognitive impairment after chemotherapy,in order to provide novel insights and approaches for the treatment of CI-related diseases.Studies have shown that the mechanism by which MET intervenes in CI mainly includes regulatingβ-amyloid protein and tau protein metabolism,reducing insulin resistance,inhibiting neuroinflammation,improving synaptic plasticity,improving mitochondrial dysfunction,regulating gut microbiota and lipid metabolism,etc.Future research needs to be conducted through interdisciplinary collaboration,fully integrating multiple omics data,and combining advanced technologies to further reveal their mechanisms of effect.
作者
刘源
许玉珉
刘诗雨
闫化雨
杨鑫
徐红彩
吴亚博
LIU Yuan;XU Yumin;LIU Shiyu;YAN Huayu;YANG Xin;XU Hongcai;WU Yabo(Dept.of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,China;The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine,Zhengzhou 450046,China)
出处
《中国药房》
北大核心
2025年第15期1942-1946,共5页
China Pharmacy
基金
国家科技重大专项(No.2024ZD0522202)
河南省博士后基金项目(No.HN2022083)
河南省医学科技攻关计划省部共建项目(No.SBGJ202302101)
2024年河南省科技发展计划项目(No.242102311255)
2023年度河南省卫生健康委国家中医药传承创新中心科研专项(No.2023ZXZX1004)。
关键词
二甲双胍
认知障碍
阿尔茨海默病
糖尿病认知障碍
药理作用
机制研究
metformin
cognitive impairment
Alzheimer’s disease
diabetes cognitive impairment
pharmacological action
mechanism research
