摘要
针对我国海洋中药资源供应不足、产业开发滞后等现实问题,提出基于开放体系的海洋中药资源开发与保护利用协同机制。通过整合外来物种引入与本土资源挖掘的双向路径,在中医药理论指导下构建“外来引入-本土挖掘-濒危替代”三位一体的资源开发创新模式。运用现代多学科技术矩阵,系统攻克资源供给稳定性、性效评价标准化、炮制工艺优化、质量可控性提升等全产业链关键技术瓶颈,突破传统资源开发模式,实现从经验传承到创新利用的全链条创新。建立覆盖资源供给、性效评价、饮片炮制、质量控制、配伍组方、制剂开发、新药研发的全流程技术体系,创建基于多组学技术的海洋中药质量标志物筛选方法,开发濒危物种替代技术路径,以推动形成海洋中药资源开发与生态保护的良性循环,为构建“陆海统筹”的中药资源开发新范式提供理论支撑和技术路径,助力实现中医药现代化与海洋强国战略的协同发展。
To address the practical challenges of insufficient supply and lagging industrial develop⁃ment of marine Chinese medicine resources in China,this study proposes a collaborative mechanism for resource development,conservation,and utilization of marine Chinese medicine resources based on an open system. By integrating dual pathways of exotic species introduction and native resource exploration,we construct a trinity innovation model of “exotic introduction-native exploration-endangered substitution” under the guidance of traditional Chinese medicine(TCM) theory. Utilizing modern multidisciplinary technological matrices,we systematically tackle key technical bottlenecks throughout the entire industrial chain,including resource supply stability,standardization of performance and efficacy evaluation,optimization of processing techniques,and enhancement of quality controllability. This research breaks through traditional resource development paradigms,achieving full-chain innovation from empirical inheritance to innovative utilization:(1) Establishing a comprehensive technical system covering resource supply,efficacy evaluation,decoction piece processing,quality control,formula compatibility,preparation development,and new drug research and development;(2)Creating a quality marker screening method for marine Chinese medicine based on multi-omics technologies;(3)Developing substitution pathways for endangered species to promote a virtuous cycle between marine resource development and ecological protection. The findings provide theoretical foundations and technical routes for constructing a “ land-sea integrated” paradigm for TCM resource development, facilitating the synergistic advancement of TCM modernization and China’s maritime power strategy.
作者
付先军
FU Xianjun(Institute of Marine Chinese Medicine,Shandong University of Traditional Chinese Medicine,Key Research Laboratory of Marine Chinese Medicine Discovery and Development(State Administration of Traditional Chinese Medicine),Key Laboratory of Marine Chinese Medicine in Shandong Higher Education Institutions,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Qingdao Academy of Chinese Medical Sciences,Shandong University of Traditional Chinese Medicine,Qingdao Key Laboratory of Marine Chinese Medicine,Qingdao Key Technology Innovation Center for Deep Development and Industrialization of Marine Chinese Medicine,Qingdao 266114,China)
出处
《山东中医杂志》
2025年第8期829-834,共6页
Shandong Journal of Traditional Chinese Medicine
基金
国家中医药管理局高水平中医药重点学科建设项目(编号:zyyzdxk-2023124)
山东省泰山学者特聘专家项目(编号:tstp20240825)
山东省自然科学基金项目(编号:ZR2022LZY026)。
关键词
海洋中药
资源开发
可持续利用
外来引入
本土挖掘
marine Chinese medicine
resource development
sustainable utilization
exotic introduction
native exploration
