摘要
蛋白质翻译后修饰(PTM)在介导细胞间信号传导、调节细胞因子的表达、激活各种信号通路等生物学过程中发挥了非凡作用,对包括肿瘤、炎症等疾病的发生和发展过程产生了深远影响。PTM可通过诱导肾脏慢性炎症、促进细胞凋亡、改变细胞器稳态、加剧肾脏纤维化等方式,在急性肾损伤(AKI)向慢性肾脏病(CKD)的演变过程中发挥着关键作用。在机制上,泛素化、磷酸化、糖基化和乙酰化等PTM通过影响下游靶基因的表达,调控包括Wnt/β-catenin、Pink1/Parkin、TGF-β/Smad、NF-κB等在内的信号通路,从而对AKI向CKD的进展产生重要影响。PTM在AKI-CKD演变过程中的相关认识与研究的进展为临床防治AKI-CKD的转化提供思路。
Protein post-translational modification(PTM)plays an extraordinary role in biological processes such as mediating intercellular signal transduction,regulating the expression of cytokines,and activating various signaling pathways,and has a profound impact on the occurrence and development of diseases including tumors and inflammation.Many studies have reported that PTM plays a key role in the evolution of acute kidney injury(AKI)to chronic kidney disease(CKD)by inducing chronic renal inflammation,promoting cell apoptosis,changing organelle homeostasis,and aggravating renal fibrosis.In terms of mechanisms,protein post-translational modifications such as ubiquitination,phosphorylation,glycosylation,and acetylation affect the expression of downstream target genes and regulate signaling pathways including Wnt/β-catenin,Pink1/Parkin,TGF-β/Smad,NF-κB,etc.,thus having an important impact on the progression of AKI to CKD.With the progress of relevant understanding and research on PTM in the evolution of AKI-CKD,it provides ideas for clinical prevention and treatment of the transformation from AKI to CKD.
作者
吴晓嫔
李志鹏
张莉莉
聂晓莉
WU Xiaopin;LI Zhipeng;ZHANG Lili;NIE Xiaoli
出处
《中国医药生物技术》
2025年第4期413-419,共7页
Chinese Medicinal Biotechnology
基金
国家自然科学基金(82374340)
广东省自然科学基金(2023A1515012246)
第五批全国中医临床优秀人才研修项目(国中医药人教函[2021]271号)。
关键词
蛋白质翻译后修饰
急性肾损伤慢性化
泛素化
磷酸化
糖基化
乙酰化
protein post-translational modification
chronic acute kidney injury
ubiquitination
phosphorylation
glycosylation
acetylation
