摘要
小儿厌食症(PA)是儿科常见病,对儿童生长发育危害严重。目前主要的治疗是药物治疗,但远期疗效欠佳,寻找更安全有效的治疗方法十分必要。微生物-脑-肠轴(MGBA)是连接中枢神经系统与消化系统的通道,在PA发病机制中发挥重要作用。本文就肠道微生物、神经递质异常、肠道屏障功能受损、大脑食欲调节中枢功能紊乱等对PA的影响,以及基于MGBA理论对PA的治疗现状进行综述。为临床诊疗提供理论与实践参考,助力小儿厌食症综合防治策略的优化。
Pediatric anorexia(PA)is a common disease in pediatrics,which is seriously harmful to children's growth and development.At present,the main treatment is drug therapy,but the long-term efficacy is not good,so it is necessary to find a safer and more effective treatment.The microbial-brain-gut axis(MGBA)is a channel connecting the central nervous system and the digestive system and plays an important role in the pathogenesis of PA.This review summarizes the effects of intestinal microorganisms,neurotransmitter abnormalities,intestinal barrier dysfunction,and brain appetite regulation central dysfunction on PA,as well as the current status of PA treatment based on MGBA theory.It provides theoretical and practical reference for clinical diagnosis and treatment,and helps to optimize the comprehensive prevention and treatment strategy of infantile anorexia.
作者
孙文君
于莉杰
郭堃
SUN Wenjun;YU Lijie;GUO Kun(Pediatrics of Lanzhou Chengguan District People's Hospital,Lanzhou 730030,China;Pediatrics,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《四川中医》
2025年第7期213-218,共6页
Journal of Sichuan of Traditional Chinese Medicine
基金
国家自然科学基金(82160921)。
关键词
微生物-脑-肠轴
小儿厌食症
发病机制
治疗进展
Microbial-brain-gut axis
Infantile anorexia
Pathogenesis
Progress in treatment
