摘要
目的探讨脑小血管病(cerebral small vessel disease,CSVD)患者血管衰老指标肱踝脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)、心踝血管指数(cardio-ankle vascular index,CAVI)、踝肱指数(ankle-brachial index,ABI)与磁共振成像(magnetic resonance imaging,MRI)总负荷评分的相关性。方法回顾性选取2023年11月至2024年10月华北理工大学附属医院神经内科收治的CSVD患者200例,依据MRI总负荷评分结果分为低负荷(0~1分)组103例,高负荷(2~4分)组97例。采用动脉硬化监测装置(VS-1500A)检测baPWV、CAVI、ABI值,分析三者与MRI总负荷评分的关系,并探讨三者对CSVD患者MRI总负荷评分的预测价值。结果与低负荷组相比,高负荷组体质量指数、同型半胱氨酸、尿酸水平、baPWV、CAVI显著增高,ABI显著降低,差异有统计学意义(P<0.01);多因素logistic分析显示,baPWV、CAVI、ABI是CSVD患者MRI高负荷评分的独立影响因素。Spearman相关性分析显示,baPWV、CAVI值与CSVD患者MRI总负荷评分呈正相关(r=0.589,P=0.000;r=0.458,P=0.000),ABI与其呈负相关(r=-0.352,P=0.000)。ROC曲线分析显示,baPWV(曲线下面积为0.816,P=0.000)、CAVI(曲线下面积为0.725,P=0.000)及ABI(曲线下面积为0.676,P=0.000)均可预测CSVD患者MRI高负荷评分。结论baPWV、CAVI与CSVD患者MRI总负荷评分呈正相关,ABI与其呈负相关。baPWV、CAVI、ABI对CSVD患者MRI高负荷均有预测作用,其中baPWV预测价值最高。
Objective To investigate the correlation of vascular senescence indicators,brachial-ankle pulse wave velocity(baPWV),cardio-ankle vascular index(CAVI),ankle-brachial index(ABI)with total burden of MRI in patients with cerebral small vessel disease(CSVD).Methods A total of 200 CSVD patients admitted to our hospital from November 2023 to October 2024 were retrospectively recruited,and based on their total MRI burden,they were divided into a low-burden group(score:0-1,103 cases)and a high-burden group(score:2-4,97 cases).A atherosclerosis monitoring device(VS-1500A)was used to detect baPWV,CAVI,and ABI values.The relationships of the three indicators with total MRI burden score and their predictive values for the burden score were analyzed.Results The high-burden group had significantly higher BMI,elevated homocysteine and uric acid levels,and increased baPWV and CAVI,but lower ABI than the low-burden group(P<0.01).Multivariate logistic analysis showed that baPWV,CAVI and ABI were independent influencing factors for high MRI burden of CSVD patients.Spearman correlation analysis showed that baPWV and CAVI values were positively correlated(r=0.589,P=0.000;r=0.458,P=0.000),and ABI was negatively correlated with the total MRI burden score of CSVD patients(r=-0.352,P=0.000).ROC curve analysis showed that baPWV(AUC=0.816,P=0.000),CAVI(AUC=0.725,P=0.000)and ABI(AUC=0.676,P=0.000)were all predictors for high MRI burden score in CSVD patients.Conclusion baPWV and CAVI are positively,and ABI is negatively correlated with the total MRI burden score of CSVD patients.baPWV,CAVI and ABI show higher predictive value for the high burden score,with baPWV most significant.
作者
崔啸宇
范颖
李海波
马琳颖
刘斌
吴小坤
毛文静
张晋霞
Cui Xiaoyu;Fan Ying;Li Haibo;Ma Linying;Liu Bin;Wu Xiaokun;Mao Wenjing;Zhang Jinxia(First Department of Neurology,the Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,Hebei Province,China)
出处
《中华老年心脑血管病杂志》
北大核心
2025年第8期1071-1075,共5页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
河北省医学科学研究课题计划项目(20231276)。
关键词
大脑小血管疾病
磁共振成像
心踝血管指数
踝肱指数
cerebral small vessel diseases
magnetic resonance imaging
cardio ankle vascular index
ankle brachial index
