摘要
目的分析糖皮质激素调节蛋白激酶1(SGK1)、血管内皮生长因子A(VEGFA)对晚期胃癌甲状腺不良事件的预测价值。方法于2023年5月到2024年5月,选取秦皇岛市第一医院收治的106例晚期胃癌患者为研究对象。并依据106例晚期胃癌患者是否发生甲状腺不良事件分组,其中未发生甲状腺不良事件有72例(未发生组),发生甲状腺不良事件有34例(发生组),对比分析两组SGK1、VEGFA水平检测,行单因素、Logistics回归分析可能影响甲状腺不良事件发生的风险因素,ROC曲线分析SGK1、VEGFA对甲状腺不良事件的预测价值。结果未发生组与发生组患者性别、年龄、病理类型、手术史、放疗史、靶向史、免疫抑制剂类型对比(P>0.05);与未发生组比,发生组甲状腺抗体阳性率、SGK1、VEGFA水平升高(P<0.05)。4级甲状腺不良事件患者SGK1、VEGFA水平高于1级、2级、3级甲状腺不良事件患者(P<0.05)。以甲状腺不良事件是否发生为因变量(未发生=0;发生=1),多因素Logistics回归分析结果显示甲状腺抗体、SGK1、VEGFA为甲状腺不良事件发生的主要因素(P<0.05)。Spearman秩相关分析显示SGK1、VEGFA与晚期胃癌甲状腺不良事件情况呈正相关(P<0.05)。ROC曲线显示,与SGK1、VEGFA单项诊断相比,SGK1联合VEGFA预测甲状腺不良事件的敏感性、准确性升高(P<0.05)。结论发生甲状腺不良事件的晚期胃癌患者SGK1、VEGFA水平升高显著,且随严重程度的加重,SGK1、VEGFA水平升高加剧,SGK1、VEGFA联合检测对甲状腺不良事件的预测价值理想。
Objective To analyze the predictive value of glucocorticoid-regulated protein kinase 1(SGK1)and vascu-lar endothelial growth factor A(VEGFA)for thyroid adverse events in advanced gastric cancer.Methods From May 2023 to May 2024,106 cases of advanced gastric cancer patients admitted to the First Hospital of Qinhuangdao were se-lected as study subjects.The 106 patients with advanced gastric cancer were grouped according to whether or not ad-verse thyroid events occurred,of which 72 cases did not have adverse thyroid events(the non-occurring group)and 34 cases had adverse thyroid events(the occurring group),and the two groups were compared and analyzed in terms of the detection of the levels of SGK1 and VEGFA,and risk factors that might affect the occurrence of adverse thyroid events were analyzed by univariate,logistic regression,and ROC curves were used to analyze the effects of SGK1 and VEGFA on the occurrence of adverse thyroid events.ROC curves were performed to analyze the predictive value of SGK1 and VEGFA for adverse thyroid events.Results There was no significant difference in gender,age,pathological type,surgi-cal history,radiotherapy history,targeted history and type of immunity inhibitor between the non-occurring group and the occurring group(P>0.05);Compared with non-occurrence group,the positive rate of thyroid antibody,SGK1 and VEGFA levels in occurrence group were increased(P<0.05).The levels of SGK1 and VEGFA in grade 4 patients were higher than those in grade 1,grade 2 and grade 3 patients(P<0.05).The levels of SGK1 and VEGFA in patients with grade 3 adverse thyroid events were higher than those in patients with grade 4 adverse thyroid events(P<0.05).The occurrence of thyroid adverse events was the dependent variable(no occurrence=0;Occurrence=1),the results of multi-factor Logistics regression analysis showed that thyroid antibody,SGK1 and VEGFA were the main factors af-fecting the occurrence of thyroid adverse events(P<0.05).Spearman rank correlation analysis showed a positive corre-lation between SGK1,VEGFA and thyroid adverse event profile in advanced gastric cancer(P<0.05).ROC curve showed that compared with single diagnosis of SGK1 and VEGFA,the sensitivity and accuracy of SGK1 combined with VEGFA in predicting thyroid adverse events were increased(P<0.05).Conclusion SGK1 and VEGFA levels were significantly elevated in advanced gastric cancer patients who developed thyroid adverse events,and the elevation of SGK1 and VEGFA levels intensified with the severity of the disease,and the combination of SGK1 and VEGFA assay had ideal predictive value for thyroid adverse events.
作者
陈兰兰
周访
孔祥蕾
高立明
徐红梅
卢熹微
刘娇
CHEN Lanlan;ZHOU Fang;KONG Xianglei;GAO Liming;XU Hongmei;LU Xiwei;LIU Jiao(Department of Oncology of The First Hospital of Qinhuangdao,Qinhuangdao 066000,China;Department of Endocrinology of Qinhuangdao Port Hospital,Qinhuangdao 066000,China)
出处
《中国实验诊断学》
2025年第7期777-782,共6页
Chinese Journal of Laboratory Diagnosis
基金
河北省医学科学研究课题计划20231891。
关键词
晚期胃癌
糖皮质激素调节蛋白激酶1
血管内皮生长因子A
甲状腺不良事件
Advanced gastric cancer
Glucocorticoid-regulated protein kinase 1
Vascular endothelial growth factor A
Thyroid adverseevents
Predictive value
