摘要
目的探究成都市双流区新报告HIV/AIDS病例首次CD4^(+)T淋巴细胞检测结果的影响因素,为调整防控策略提供理论依据。方法采用流式细胞术对2015—2023年成都市双流区新报告HIV/AIDS病例静脉血样进行CD4+细胞检测,所得数据进行逐步Logistic回归分析、χ^(2)检验、Spearman相关性分析。结果2015—2023年双流区新报告HIV/AIDS病例(2223例)完成首次CD4^(+)细胞计数检测的病例数为2115例(95.14%),首次CD4^(+)细胞计数<200个/μL 577例(27.28%),其中确诊后14天内接受CD4^(+)细胞计数检测694例(32.81%)。2015—2023年晚发现率从45.00%降至24.40%,平均为35.60%,整体呈下降趋势。逐步Logistic分析结果显示,最终的模型仅纳入性别、年龄组、人群分类、户籍地区类型和样本来源,结果显示,女性相较于男性更不容易晚发现(OR=0.717,95%CI:0.569~0.902),30~50岁和>50岁比<30岁更容易晚发现(OR=4.059,95%CI:2.949~5.635),民工及务农人员相较于家政家务及待业更不容易晚发现(OR=0.773,95%CI:0.605~0.987),其他区市县相较于本区县更不容易晚发现(OR=0.674,95%CI:0.573~0.837),样本来源为重点人群检测相较于医疗机构检测更不容易晚发现(OR=0.625,95%CI:0.477~0.816)。结论2015—2023年成都市双流区新报告HIV/AIDS病例首次CD4+细胞计数检测率较高,检测及时性较差,晚发现率有下降趋势。应继续加强宣传,扩大检测面,提高检测及时性,进一步降低晚发现率,减少“发现即发病”现象。
Objective To investigate the influencing factors of the first CD4^(+)T-lymphocyte test results of newly reported HIV/AIDS cases in Shuangliu District of Chengdu City,and to provide a theoretical basis for adjusting prevention and control strategies.Methods CD4^(+)cells were detected by flow cytometry,and the obtained data were subjected to stepwise logistic regression analysis,χ^(2) test,and Spearman correlation analysis.Results The number of newly reported HIV/AIDS cases(2,223 cases)in the district from 2015—2023 who completed the first CD4^(+)cell count test was 2,115 cases(95.14%),with a first CD4^(+)cell count<200 cells/μl in 577 cases(27.28%),of which 694 cases(32.81%)underwent the CD4^(+)cell count test within 14 days of diagnosis.The late detection rate decreased from 45.00%to 24.40%with an average of 35.60%from 2015—2023,showing an overall decreasing trend.The results of the stepwise logistic analysis showed that the final model incorporated only gender,age group,population classification,type of domicile area,and sample source,which showed that females were less likely to be detected late compared to males(OR=0.717,95%CI:0.569~0.902),30~50 years old and>50 years old were more likely to be detected late compared to<30 years old(OR=4.059,95%CI:2.949~5.635),migrant laborers and agricultural workers were less likely to be detected late compared to those housekeeping and unemployment(OR=0.773,95%CI:0.605~0.987),and other districts,cities and counties were less likely to be detected late compared to their districts and counties(OR=0.674,95%CI:0.573~0.837).Late detection was less likely to be detected in different districts and counties than in their districts and counties,and the source of the samples was the key population testing compared to the testing of medical institutions(OR=0.625,95%CI:0.477~0.816).Conclusions From 2015 to 2023,newly reported HIV/AIDS cases in the first CD4^(+)cell count detection rate in Shuangliu District of Chengdu was higher,the timeliness of detection was poorer,and the rate of late detection had a downward trend.We should continue to strengthen publicity,expand the detection surface,improve the timeliness of detection,further reduce the late detection rate and reduce the phenomenon of“symptomatic upon detection”.
作者
杨瑶
张燚
陈冬梅
彭红霞
孟勤
谢嘉渝
阳凤娇
YANG Yao;ZHANG Yi;CHEN Dongmei;PENG Hongxia;MENG Qin;XIE Jiayu;YANG Fengjiao(Center for Disease Control and Prevention,Shuangliu District 610200,Chengdu City,Sichuan Province,China)
出处
《预防医学情报杂志》
2025年第7期873-880,共8页
Journal of Preventive Medicine Information
