摘要
目的:探讨我国近年来门诊2型糖尿病患者降糖方案复杂性变化趋势,为保障患者依从性、优化降糖方案选择提供参考。方法:抽取2018—2022年我国9个城市83家医院2型糖尿病患者的门诊抗糖尿病药处方,对各类抗糖尿病药使用率、抗糖尿病药联合应用情况、固定剂量复方制剂使用情况以及降糖方案用药复杂性指数进行统计分析。结果:2018—2022年,新型口服降糖药二肽基肽酶4抑制剂、钠-葡萄糖耦联转运体2抑制剂、胰高血糖素样肽-1受体激动剂使用率明显升高;联合应用2种抗糖尿病药的患者所占比例有降低趋势,而联合应用4种及4种以上抗糖尿病药的患者所占比例明显升高(P<0.05);固定剂量复方制剂的使用率有升高趋势;患者使用抗糖尿病药的平均用药复杂性指数有明显降低趋势(P<0.05)。结论:临床医师及临床药师应关注糖尿病患者的降糖方案复杂性,以保障患者依从性及降糖效果。新型口服降糖药、固定剂量复方制剂使用较为方便,给临床降糖方案提供了更多选择,同时有助于减少降糖方案的复杂性,在具体使用中可根据患者的个体化需求选择。
OBJECTIVE:To probe into the change trends of complexity of anti-hyperglycemic regimens for outpatients with type 2 diabetes mellitus in China in recent years,and to provide references for ensuring patients’compliance and optimizing the selection of hypoglycemic treatment regimens.METHODS:Outpatient prescriptions of antidiabetic drugs for patients with type 2 diabetes mellitus in 83 hospitals from 9 cities in China from 2018 to 2022 were extracted,the usage rate of various antidiabetic drugs,the combined application of antidiabetic drugs,the application of fixed-dose combination and the medication regimen complexity index of hypoglycemic medication were statistically analyzed.RESULTS:From 2018 to 2022,the usage rates of new oral antidiabetic drugs including dipeptidyl peptidase 4 inhibitors,sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists increased significantly.The proportion of patients received two types of antidiabetic drugs in combination showed a decreasing trend,while the proportion of patients received four or more types of antidiabetic drugs in combination increased significantly(P<0.05).The usage rate of fixed-dose combination showed an increasing trend.The average medication regimen complexity index of patients receiving antidiabetic drugs showed a significant decreasing trend(P<0.05).CONCLUSIONS:Clinicians and pharmacists should pay attention to the complexity of anti-hyperglycemic regimens for diabetic patients to ensure patients’compliance and anti-hyperglycemic effect.New oral antidiabetic drugs and fixed-dose combination are more convenient,which provide more options for clinical anti-hyperglycemic regimens,and helps to reduce the complexity of anti-hyperglycemic regimens.In specific use,it can be selected according to the individualized needs.
作者
廖音
李丹丹
程晟
李婧
李新刚
LIAO Yin;LI Dandan;CHENG Sheng;LI Jing;LI Xingang(Dept.of Pharmacy,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100050,China)
出处
《中国医院用药评价与分析》
2025年第7期869-871,875,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
北京慢性病防治与科技教育研究会2023糖尿病防治及管理研究项目(No.MBZX00422023007)。
关键词
2型糖尿病
降糖方案
固定剂量复方制剂
用药复杂性指数
Type 2 diabetes mellitus
Anti-hyperglycemic regimens
Fixed-dose combination
Medication regimen complexity index
