摘要
血管新生是指内皮细胞在原有微静脉的基础上,通过增殖、分化和迁移,以芽生或者套叠的形式生成新的毛细血管的过程。动脉粥样硬化斑块内的新生血管会严重影响斑块的稳定性,抑制斑块内血管新生已成为动脉粥样硬化防治研究的新方向。在细胞焦亡的过程中,炎症因子的激活会影响内皮细胞的功能,促进新生血管管腔的形成和重塑。而新血管形成后通过改变氧分压和营养供应等环境因素,会加剧炎症反应,推动动脉粥样硬化进一步发展。因此细胞焦亡与血管新生相互影响、紧密相关,本文就二者之间的关系进行综述,以期为动脉粥样硬化的治疗提供新思路。
Neovascularization is the process by which endothelial cells generate new capillaries in the form of sprouting or nesting on the basis of the original microvessels through proliferation,differentiation and migration.Neovascularization within atherosclerotic plaques can seriously affect the stability of plaque,and inhibition of intra-plaque neovascularization has become a new direction on the prevention and treatment research of atherosclerosis.During the process of cellular pyroptosis,the activation of inflammatory factors affects the function of endothelial cells and promotes the formation and remodeling of the neovascular lumen.And the formation of new blood vessels exacerbates the inflammatory response by altering environmental factors such as oxygen partial pressure and nutrient supply,driving further development of atherosclerosis.Therefore,pyroptosis and neovascularization are closely related to each other,and this article reviews the relationship between the two,with a view of providing new ideas for the treatment of atherosclerosis.
作者
宫荣荣
蔡宏文
Gong Rongrong;Cai Hongwen(Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,Zhejiang,China;Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China)
出处
《中国医学前沿杂志(电子版)》
北大核心
2025年第6期84-90,共7页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
国家自然科学基金面上项目(81973579)。
关键词
动脉粥样硬化
细胞焦亡
血管新生
内皮细胞
炎症
Atherosclerosis
Cellular pyroptosis
Neovascularization
Endothelial cell
Inflammation
