摘要
目的通过总结白血病动物模型的特点,为建立理想的白血病动物模型提供参考依据。方法以“白血病”和“动物”为主题在中国知网数据库进行检索,筛选出2010年1月-2024年8月有关白血病动物实验相关性文献,通过Excel 2017表格建立数据库,对其研究动物品系、造模方法、检测指标等内容进行整理,分析白血病动物模型特点。结果经过对比分析发现,造模时的动物品系分别以BALB/C-nude小鼠(40次,29.86%)和NOD/SCID小鼠(32次,23.88%)为主,造模方法以移植细胞(127次,93.38%)为主,检测指标以病理组织(80次,14.84%)、血涂片(75次,13.91%)、一般情况(73次,13.54%)、骨髓涂片(73次,13.54%)、流式细胞术(55次,10.20%)、血常规(50次,9.28%)为主。结论现有的白血病动物模型种类复杂多样。
Objective To provide a reference basis for the establishment of ideal animal models of leukemia,the characteristics of animal models of leukemia was summarized.Methods The themes of"leukemia"and"animal"were searched in CNKI databases.The relevant literature on animal experiments of leukemia from January 2010 to August 2024 were screened.And a database by Excel 2017 tables was established by organizing their research animal strains,modeling methods and testing indexes to analyze the characteristics of leukemia animal models.Results After comparative analysis,it was found that the animal strains in modeling were BALB/C-nude mice(40 times,29.86%)and NOD/SCID mice(32 times,23.88%),respectively.The modeling method was transplanted cells(127 times,93.38%),and the detection indexes were pathological tissues(80 times,14.84%),blood smears(75 times.13.91%),general condition(73 times,13.54%),bone marrow smear(73 times,13.54%),flow cytometry(55 times,10.20%),blood routine(50 times,9.28%).Conclusion The existing animal models of leukemia are complex and diverse.
作者
佘琳静
屈秉聪
周天豹
郭琳
谢逸轩
白明
苗明三
SHE Linjing;QU Bingcong;ZHOU Tianbao;GUO Lin;XIE Yixuan;BAI Ming;MIAO Mingsan(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第7期1914-1921,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会重大课题(82074038):基于体表神经-内分泌-免疫网络的白芷外治黄褐斑分子机制研究,负责人:苗明三
河南省科学技术厅河南省重大公益专项(201300310100):豫产道地中药材资源综合利用中心,负责人:苗明三
国家中医药管理局(国中医药人教函2022-6):岐黄学者,负责人:苗明三。
关键词
白血病
动物模型
评价指标
数据挖掘
Leukemia
Animal models
Evaluation indicators
Data mining
