摘要
目的分析出血性脑卒中患者血清神经元特异性烯醇化酶(NSE)、白蛋白(ALB)水平与其病情进展的相关性。方法选取2023年1月—2024年12月牡丹江医科大学附属红旗医院收治的106例出血性脑卒中患者为研究对象,检测患者入院时血清NSE、ALB水平,入院48 h后根据患者病情进展将其分为进展组与无进展组,采用多因素Logistic回归分析与受试者工作曲线(ROC)分析血清NSE、ALB水平与病情进展的关系。结果入院48 h后评估结果显示,共47例患者病情进展,病情进展率为44.34%(47/106)。两组舒张压、收缩压、美国国立卫生研究院卒中量表(NIHSS)评分对比,组间差异有统计学意义(P<0.05)。入院时,进展组NSE水平高于未进展组,ALB水平低于未进展组,组间差异有统计学意义(P<0.05)。Logistic回归分析结果显示,NIHSS评分、血清NSE、ALB水平均是病情进展的独立危险因素(P<0.05)。ROC曲线分析显示,血清NSE、ALB水平联合检测预测患者病情进展的曲线下面积高于单独检测,为0.882。结论血清NSE、ALB水平均是出血性脑卒中患者的病情进展的独立危险因素,且联合检测对病情进展具有更高的预测价值,临床中应高度关注。
Objective To analyze the correlation between serum neuron specific enolase(NSE)and albumin(ALB)levels and disease progression in patients with hemorrhagic stroke.Methods A total of 106 patients with hemorrhagic stroke admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from January 2023 to December 2024 were selected as the research subjects.The levels of serum NSE and ALB of the patients at admission were detected.48 hours after admission,the patients were divided into a progression group and a non-progression group according to the disease progression.Multivariate Logistic regression analysis and receiver operating curve(ROC)were used to analyze the relationship between serum NSE and ALB levels and disease progression.Results The evaluation results 48 hours after admission showed that 47 patients had disease progression,and the disease progression rate was 44.34%(47/106).There were significant differences in diastolic blood pressure,systolic blood pressure and National Institutes of Health Stroke Scale(NIHSS)scores between the two groups(P<0.05).On admission,the NSE level of the progression group was higher than that of the non-progression group,and the ALB level was lower than that of the non-progression group,and the differences between the two groups were statistically significant(P<0.05).Logistic regression analysis showed that NIHSS score,serum NSE and ALB level were independent risk factors for disease progression(P<0.05).ROC curve analysis showed that the area under the curve of serum NSE and ALB levels combined detection in predicting disease progression was higher than that of single detection,which was 0.882.Conclusion Serum NSE and ALB levels are independent risk factors for disease progression in patients with hemorrhagic stroke,and the combined detection has a higher predictive value for disease progression,which should be paid more attention in clinical practice.
作者
王欣欣
杜秀兰
刘大年
WANG Xinxin;DU Xiulan;LIU Danian(Department of NO.2 Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang 157011,China;Personnel Department,Disease Control and Prevention Center of Aimin District in Mudanjiang City,Mudanjiang 157011,China)
出处
《反射疗法与康复医学》
2025年第8期143-146,共4页
Reflexology And Rehabilitation Medicine
