摘要
目的:探讨重症脓毒症患者经艾司洛尔联合垂体后叶素治疗的效果。方法:回顾性分析2021年1月至2023年12月于漳州正兴医院诊治的72例重症脓毒症患者临床资料,依据治疗方案的不同分为对照组和观察组,各36例。对照组患者接受垂体后叶素治疗,观察组患者接受艾司洛尔联合垂体后叶素治疗。比较两组患者临床疗效,血流动力学指标[心率(HR)、平均动脉压(MAP)],氧合指数(OI),血乳酸(LaC)水平,血清炎症因子[血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平,心肌功能[血清肌钙蛋白I(cTnI)、B型尿钠肽(BNP)、肌酸激酶同工酶(CK-MB)]。结果:观察组患者治疗总有效率(97.22%)明显高于对照组(83.33%),差异有统计学意义(P<0.05);治疗后24 h,两组患者血清PCT、hs-CRP、IL-6、cTnI、BNP、CK-MB、LaC水平及HR均明显降低,且观察组均低于对照组,差异均有统计学意义(P<0.05);两组患者MAP、OI均明显升高,且观察组均高于对照组,差异均有统计学意义(P<0.05)。结论:对重症脓毒症患者进行艾司洛尔联合垂体后叶素治疗可提高临床疗效,增强心肌功能,有效改善血流动力学指标,减轻炎症反应及血管损伤,纠正缺氧状态。
Objective To explore the therapeutic effect of esmolol combined with posterior pituitary extract in the treatment of severe sepsis patients.Methods The clinical data of 72 patients with severe sepsis treated in Zhangzhou Zhengxing Hospital from January 2021 to December 2023 were retrospectively analyzed.The patients were divided into a control group and an observation group,with 36 cases in each group,based on the treatment plan.The control group was treated with posterior pituitary extract,while the observation group was treated with esmolol combined with posterior pituitary extract.The clinical efficacy,hemodynamic parameters[heart rate(HR),mean arterial pressure(MAP)],oxygenation index(OI),blood lactate(LaC),serum inflammatory factors[procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)],and myocardial function[serum troponin I(cTnI),B-type natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB)]of the two groups were compared.Results The total effective rate of the observation group(97.22%)was significantly higher than that of the control group(83.33%),and the difference was statistically significant(P<0.05).After 24 hours of treatment,the levels of serum PCT,hs-CRP,IL-6,cTnI,BNP,CK-MB,LaC,and HR in both groups were significantly decreased,and those in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Meanwhile,MAP and OI in both groups were significantly increased,and those in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion The treatment of severe sepsis patients with esmolol combined with posterior pituitary extract can improve the clinical efficacy,enhance myocardial function,effectively improve the hemodynamic state of patients,reduce the inflammatory response and vascular injury,and correct hypoxia.
作者
何继成
HE Jicheng(Department of Critical Care Medicine,Zhangzhou Zhengxing Hospital,Fujian Zhangzhou 363099)
出处
《深圳中西医结合杂志》
2025年第6期17-20,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
重症脓毒症
艾司洛尔
垂体后叶素
心肌功能
Severe sepsis
Esmolol
Posterior pituitary extract
Myocardial function
