摘要
目的探究万古霉素骨水泥联合生肌玉红膏改善糖尿病足患者创面感染及愈合进程。方法选取2022年03月-2024年03月平顶山中医医院糖尿病足患者共80例。根据随机数字表法分为对照组和观察组,各40例。对照组采用万古霉素骨水泥治疗,观察组在对照组基础上联合生肌玉红膏治疗。比较两组血管新生指标[内皮生长因子(VEGF)、内皮抑素(ES)、血管生成素-2(Ang-2)]、创面细菌培养阳性检出情况、创面愈合情况和生活质量改善情况。结果治疗后,两组VEGF水平升高,ES、Ang-2水平均降低(P<0.05)。观察组VEGF水平高于对照组,ES、Ang-2水平低于对照组(P<0.05);治疗7 d、15 d后,观察组创面细菌培养阳性显著低于对照组(P<0.05);经治疗,两组创面均有所缩小,且观察组创面面积较对照组更小(P<0.05)。观察组创面愈合速度更快,愈合率也高于对照组(P<0.05);治疗后,两组疼痛、行走方式、生活满意度、总积分均降低,且观察组低于对照组(P<0.05)。结论万古霉素骨水泥联合生肌玉红膏对DFI患者效果显著,可促进血管新生,减少细菌感染,加快创面愈合,增强生活质量。
Objective To assess the impact of vancomycin bone cement+Shengji Yuhong ointment on wound infection and healing in diabetic foot patients.Methods Eighty diabetic foot patients at Pingdingshan Hospital of TCM(2022-2024)were randomized to control(40)and observation(40)groups,treated with vancomycin bone cement alone or combined with Shengji Yuhong ointment.Comparisons included angiogenesis markers(VEGF,ES,Ang-2),wound infection,healing,and QOL improvements.Results Post-treatment,VEGF increased and ES,Ang-2 decreased in both groups(P<0.05).The observation group had higher VEGF and lower ES,Ang-2(P<0.05).Bacterial culture positivity was lower in the observation group at 7&15 days(P<0.05).Wound area decreased more in the observation group(P<0.05),with shorter healing time and higher healing rate(P<0.05).Improvements in pain,walking,life satisfaction,and total scores were greater in the observation group(P<0.05).Conclusions Vancomycin bone cement+Shengji Yuhong ointment significantly benefits DFI patients by promoting angiogenesis,reducing infection,accelerating wound healing,and improving QOL.
作者
栗春芳
马立人
罗秀荣
张现峰
LI Chunfang;MA Liren;LUO Xiurong;ZHANG Xianfeng(Pingdingshan Traditional Chinese Medicine Hospital Peripheral Vascular Disease Hospital Pingdingshan,Henan 467000)
出处
《航空航天医学杂志》
2025年第7期779-781,共3页
Journal of Aerospace medicine
关键词
万古霉素骨水泥
生肌玉红膏
糖尿病足
创面感染
愈合进程
Vancomycin bone cement
Shengji Yuhong ointment
Diabetic foot
Wound infection
Healing process
