摘要
通过一锅法三组分反应,合成了一系列氨基烷基萘酚类化合物,并对其抗植物病原真菌和杀线虫活性进行了评估.结果表明,在200~25μg/mL浓度范围内,化合物8对链格孢菌的抑制活性约为50%,且抑制效果与浓度无明显相关性.活体抑菌实验表明,化合物8在50μg/mL浓度下具有与阳性对照嘧菌酯相当的抑菌作用.此外,在温室试管实验中,合成的化合物对南方根结线虫表现出显著的抑制活性,其中化合物10在10μg/mL浓度下能显著减少根结数量,抑制率高达90.91%,与阳性对照氟吡菌酰胺相当.综上,氨基烷基萘酚类化合物作为一种新型农药活性物质,具有潜在的抑菌和杀线虫双重功效,研究结果为开发环境友好型多靶点农药提供了新思路.
A series of amino-alkyl naphthol compounds was synthesized through a one-pot three⁃component reaction,their antifungal activity against plant pathogenic fungi and nematicidal activity were evaluated.The results showed that compound 8 exhibited about 50%inhibitory activity against Alternaria alternate at concentrations ranging from 200μg/mL to 25μg/mL,and the inhibitory effect was not significantly correlated with concentration.In vivo antifungal experiments indicated that compound 8 at a concentration of 50μg/mL had a therapeutic effect comparable to the positive control pyrimethanil.Additionally,in greenhouse test tube experiments,the synthesized compounds showed significant inhibitory activity against southern root-knot nematodes,with compound 10 significantly reducing the number of galls at a concentration of 10μg/mL,achieving an inhibition rate of 90.91%,which is comparable to the positive control fluopyram.In summary,amino-alkyl naphthol compounds,as a new type of pesticide active substance,have potential dual effects of antibiosis and nematicide,and the aforementioned research provides new ideas for the development of environmentally friendly multi-target pesticides.
作者
张琦璘
史衍常
高堃
王林松
宋亚东
王郁森
李鹏程
刘松
邢荣娥
宋琳
秦玉坤
ZHANG Qilin;SHI Yanchang;GAO Kun;WANG Linsong;SONG Yadong;WANG Yusen;LI Pengcheng;LIU Song;XING Ronge;SONG Lin;QIN Yukun(Bioengineering College,Qingdao University of Science and Technology,Qingdao 266042,China;Key Laboratory of Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China;Functional Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao 266237,China)
出处
《高等学校化学学报》
北大核心
2025年第8期43-53,共11页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:42076126)
山东省重点研发计划重大科技创新项目(批准号:2022CXGC020413)
青岛市科技惠民示范专项项目(批准号:25-1-5-xdny-7-nsh)
中央引导地方科技发展资金项目(批准号:2024ZY0039)
现代农业产业技术体系专项项目(批准号:CARS-49)资助.
