摘要
口腔鳞状细胞癌(OSCC)是原发于口腔黏膜鳞状上皮的恶性病变,占口腔颌面部恶性肿瘤的80%以上,其主要致病因素包括烟草使用、酗酒及咀嚼槟榔等,在我国发病率总体呈上升趋势,严重威胁国民健康。OSCC具有较高的局部侵袭性,早期诊断对改善预后至关重要。其诊疗涉及口腔颌面外科、头颈外科、肿瘤放疗科、肿瘤内科、修复重建科、影像科、病理科及营养支持团队等多学科紧密协作。鉴于口腔鳞癌疾病负担加重及多学科协作诊疗模式快速发展,专家组基于循证医学证据,经充分讨论形成以“防筛诊治康”为核心,覆盖口腔鳞癌患者全病程管理的整合诊治共识,旨在为临床实践提供规范化指导。
Oral squamous cell carcinoma(OSCC)is a malignant lesion originating from the oral mucosal squamous epithelium,accounting for over 80%of oral and maxillofacial malignancies.Key etiological factors include tobacco,alcohol abuse,and betel quid chewing.In China,its incidence has shown an overall upward trend,posing a significant threat to public health.OSCC exhibits high local invasiveness,making early diagnosis critical for improving prognosis.Its clinical management requires close multidisciplinary collaboration among oral and maxillofacial surgery,head and neck surgery,radiation oncology,medical oncology,reconstructive surgery,radiology,pathology,and nutritional support teams.Given the increasing disease burden of OSCC and rapid development of multidisciplinary collaborative models,an expert panel has formulated this integrated management consensus based on evidence-based medicine and extensive deliberation.Centered on the'Prevention-Screening-Diagnosis-Treatment-Rehabilitation'framework,the consensus provides comprehensive guidance for the entire disease course of OSCC patients,aiming to standardize clinical practice.
作者
孙沫逸
何宗轩
徐豪越
李小莹
张杰
陆海军
展晓红
郝大鹏
白石柱
郭伟
唐瞻贵
任国欣
孟箭
孙志军
李吉辰
何悦
李春洁
秦力铮
杨凯
席庆
孔琳
韩冰
卜令学
冯元勇
宋凯
韩红钰
李洁莹
倪前伟
李昀
柴娟
杨小琛
胡漫
徐名金
尚伟
SUN Moyi;HE Zongxuan;XU Haoyue;LI Xiaoying;ZHANG Jie;LU Haijun;ZHAN Xiaohong;HAO Da peng;BAI Shizhu;GUO Wei;TANG Zhangui;REN Guoxin;MENG Jian;SUN Zhijun;LI Jichen;HE Yue;LI Chunjie;QIN Lizheng;YANG Kai;XI Qing;KONG Lin;HAN Bing;BU Lingxue;FENG Yuanyong;SONG Kai;HAN Hongyu;LI Jieying;NI Qianwei;LI Yun;CHAI Juan;YANG Xiaochen;HU Man;XU Mingjin;SHANG Wei(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Oral and Maxillofacial Surgery,School of Stomatology,The Fourth Military Medical University,Xi'an 710032,China;Department of Oral&Maxillofacial Surgery,the Affiliated Hospital of Qingdao University,Shandong;Department of Oral and Maxillofacial Surgery,School of Stomatology,the F1ourth Military Medical University,Xi'an;Department of Oral and Maxillofacial Surgery,School and hospital of Stomatology,Peking University,Beijing;Department of Radiation Oncology,the Affiliated Hospital of Qingdao University,Shandong;Department of Pathology,the Affiliated Hospital of Qingdao University,Shandong;Department of Radiology,Affiliated Hospital of Qingdao University;Digital Dentistry Center,School of Stomatology,The Fourth Military Medical University,Xi'an;Department of Oro maxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine;Department of Oral and Maxillofacial Surgery,Xiangya School of Stomatology,Central South University,Changsha;Department of Oral and Maxillofacial Surgery,Xuzhou Central Hospital;Department of Oral and Maxillofacial Head Neck Oncology Surgery,School and Hospital of Stomatology,Wuhan University;Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical University;Department of Head and Neck Oncology Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu;Department of Maxillofacial Oncology,Beijing Stomatological Hospital Affiliated to Capital Medical University;Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Chongqing Medical University;Oral Department of 1st Medical Center,Chinese PLA General Hospital,Beijing;Shanghai Protonand Heavy Ion Center;Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Jilin University,Changchun;Department of Prosthodontics,University of Health and Rehabilitation Sciences Qingdao Hospital;Maxillofacial Surgery Department of Xinjiang Military Region General Hospital;Department of Oral and Maxillofacial Surgery,Xi'an Medical University;Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Ji'nan)
出处
《实用口腔医学杂志》
北大核心
2025年第4期437-449,共13页
Journal of Practical Stomatology
基金
青岛大学附属医院项目(编号:QDFYQN2023203,QDFY+X2024221)。
关键词
口腔鳞状细胞癌
多学科
整合诊治
Oral squamous cell carcinoma
Multidisciplinary team
Holistic integrative management