摘要
目的探讨驴奶联合常规抗结核方案对肺结核患者临床转归及免疫功能的影响。方法选取新疆维吾尔自治区传染病医院2024年1月-12月接收的80例年龄≥60岁的肺结核患者,依据治疗方法不同分为对照组(40例,采用常规抗结核方案治疗)和观察组(40例,采用驴奶联合常规抗结核方案治疗),对比分析两组临床转归、免疫功能、生活质量及不良反应。结果观察组痰菌转阴率为90.00%,与对照组的72.50%比较,差异明显(χ^(2)=4.762,P=0.029),观察组影像学改善率为85.00%,相比于对照组的65.00%明显较高(χ^(2)=4.114,P=0.043);观察组治疗后CD4^(+)、CD4^(+)/CD8^(+)水平升高较对照组明显(t=3.976,P=0.000;t=4.218,P=0.000);观察组治疗后生活质量四项维度评分均明显提高,与对照组有显著差异(t=3.974,3.925,4.123,3.978,P均=0.000);两组不良反应无明显差异(χ^(2)=0.114,P=0.735)。结论驴奶联合常规抗结核方案可显著改善肺结核患者临床转归,调节免疫功能,提高生活质量,且安全性良好。
Objective To explore the effect of donkey milk combined with conventional anti tuberculosis regimen on the clinical outcomes and immune function of pulmonary tuberculosis patients.Methods Eighty patients aged 60 years or older with pulmonary tuberculosis who were admitted to the Infectious Disease Hospital of Xinjiang Uygur Autonomous Region from January to December 2024 were selected and divided into a control group(40 cases,treated with conventional anti tuberculosis regimen)and an observation group(40 cases,treated with donkey milk combined with conventional anti tuberculosis regimen)according to different treatment methods.The clinical outcomes,immune function,quality of life,and adverse reactions of the two groups were compared and analyzed.Results The sputum conversion rate in the observation group was 90.00%,which was significantly different from the control group’s72.50%(χ^(2)=4.762,P=0.029).Furthermore,the observation group demonstrated a significantly higher radiographic improvement rate(85.00%)vs the control group(65.00%)(χ^(2)=4.114,+P=0.043);the levels of CD4 and CD4^(+)/CD8^(+)in the observation group increased significantly after treatment compared to the control group(t=3.976,P=0.000;t=4.218,P=0.000);the four dimensions of quality of life scores in the observation group showed significant improvement after treatment,with significant differences compared to the control group(t=3.974,3.925,4.123,3.978,allP=0.000);there was no significant difference in adverse reactions between the two groups(χ^(2)=0.114,P=0.735).Conclusion The combination of donkey milk and conventional anti tuberculosis regimen can significantly improve the clinical outcomes of pulmonary tuberculosis patients,regulate immune function,improve quality of life,and has good safety.
作者
马燕
杨华
热依汗古丽·阿肯
Ma Yan;Yang Hua;Reyihanguli·A Ken(The Sixth People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830000,China)
出处
《首都食品与医药》
2025年第15期45-48,共4页
Capital Food Medicine
基金
新疆医科大学第八附属医院院级科研项目(编号:2023015)。
关键词
驴奶
常规抗结核方案
肺结核
临床转归
免疫功能
生活质量
安全性
Donkey milk
Conventional anti tuberculosis regimen
pulmonary tuberculosis
Clinical outcome
immunity
Quality of life
safety
