摘要
目的 探讨脯氨酸恒格列净片联合基础胰岛素治疗2型糖尿病(type 2 diabetes mellitus, T2DM)的效果。方法 选取2023年6月—2025年1月启东市中医院收治的90例T2DM患者,分组依据为不同治疗方法。对照组45例采用基础胰岛素治疗,观察组45例在基础胰岛素治疗基础上加用脯氨酸恒格列净片。比较血糖指标、尿白蛋白肌酐比、心血管风险标志物、低血糖发生情况。结果 治疗后,观察组糖化血红蛋白、空腹血糖、餐后2 h血糖、尿白蛋白肌酐比、超敏C反应蛋白水平及低密度脂蛋白胆固醇分别为(6.85±0.65)%、(6.03±1.21)mmol/L、(8.13±2.29)mmol/L、(18.56±5.13)mg/g、(2.00±0.60)mg/L、(3.24±0.35)mmol/L,低于对照组的(7.56±0.75)%、(7.64±1.53)mmol/L、(9.65±2.71)mmol/L、(28.56±8.56)mg/g、(3.56±1.00)mg/L、(3.75±0.40)mmol/L,差异均有统计学意义(P均<0.05)。观察组低血糖发生次数低于对照组,差异有统计学意义(P<0.05)。结论脯氨酸恒格列净片联合基础胰岛素治疗T2DM效果显著,能有效降低血糖水平,改善尿白蛋白肌酐比,调节心血管风险标志物,且低血糖发生次数较低。
Objective To investigate the effect of henagliflozin proline tablets combined with basal insulin in the treat-ment of type 2 diabetes mellitus(T2DM).Methods A total of 90 patients with T2DM admitted to Qidong Traditional Chinese Medicine Hospital from June 2023 to January 2025 were selected and grouped according to different treat-ment methods.45 cases in the control group were treated with basic insulin,and 45 cases in the observation group were treated with henagliflozin proline tablets on the basis of basic insulin therapy.The blood glucose index,urinary albumin creatinine ratio,cardiovascular risk markers and hypoglycemia were compared.Results After treatment,the levels of glycosylated hemoglobin,fasting blood glucose,2 h postprandial blood glucose,urinary albumin creatinine ra-tio,high-sensitivity C-reactive protein and low-density lipoprotein cholesterol in the observation group were(6.85±0.65)%,(6.03±1.21)mmol/L,(8.13±2.29)mmol/L,(18.56±5.13)mg/g,(2.00±0.60)mg/L,(3.24±0.35)mmol/L,respec-tively.It was lower than that of the control group[(7.56±0.75)%,(7.64±1.53)mmol/L,(9.65±2.71)mmol/L,(28.56±8.56)mg/g,(3.56±1.00)mg/L,(3.75±0.40)mmol/L],and the differences were statistically significant(all P<0.05).The incidence of hypoglycemia in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Henagliflozin proline tablets combined with basal insulin has a signifi-cant effect in the treatment of T2DM,which can effectively reduce blood glucose levels,improve urinary albumin cre-atinine ratio,regulate cardiovascular risk markers,and reduce the incidence of hypoglycemia.
作者
夏伟
XIA Wei(Endocrinology Department,Qidong Traditional Chinese Medicine Hospital,Qidong 226200,Jiangsu,China)
出处
《糖尿病新世界》
2025年第10期12-15,共4页
Diabetes New World
关键词
脯氨酸恒格列净片
基础胰岛素
2型糖尿病
尿白蛋白肌酐比
心血管风险标志物
Henagliflozin proline tablets
Basal insulin
Type 2 diabetes mellitus
Urinary albumin creatinine ratio
Cardiovascular risk markers
