摘要
目的探究血液凝血功能异常对胚胎移植成功率的影响。方法该研究回顾性分析了2020年1月—2024年8月60例接受胚胎移植治疗的女性患者。根据血液凝血功能检查结果,患者被分为凝血功能正常组(n=30)和凝血功能异常组(n=30)。比较两组患者的凝血功能指标[国际标准化比值(INR)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D-二聚体、抗磷脂抗体阳性、蛋白S缺乏]及胚胎移植成功率(胚胎着床率、临床妊娠率、流产率、活产率)。使用Logistic回归分析调整了可能的干扰因素,评估凝血功能异常对胚胎移植成功率的独立预测作用。结果两组患者在年龄、体重、基础疾病、促排卵方案等一般特征方面差异无统计学意义(P>0.05)。两组患者的INR、PT、APTT、D-二聚体、抗磷脂抗体阳性、蛋白S缺乏比较,差异有统计学意义(P<0.05)。凝血功能异常组胚胎着床率、临床妊娠率、流产率、活产率均低于凝血功能正常组,差异有统计学意义(P<0.05)。使用Logistic回归分析调整了年龄、体重、促排卵方案等可能的干扰因素,结果表明,凝血功能异常仍是胚胎移植成功率的独立预测因素。结论血液凝血功能异常显著降低了胚胎移植的成功率。凝血功能异常通过影响胚胎着床率、临床妊娠率及活产率,成为胚胎移植成功率的重要独立预测因素。因此,在胚胎移植前对凝血功能进行评估,并根据凝血异常类型采取个性化治疗方案,可能有助于提高胚胎移植的成功率。
Objective To explore the influence of abnormal blood coagulation function on the success rate of embryo transfer.Methods This retrospective study analyzed 60 female patients who underwent embryo transfer treatment from January 2020 to August 2024.According to the results of blood coagulation tests,the patients were divided into normal coagulation function group(n=30)and abnormal coagulation function group(n=30).The coagulation indicators(International Normalized Ratio(INR),prothrombin Time(PT),activated partial thromboplastin time(APTT),D-dimer,positive antiphospholipid antibodies,protein S deficiency)and embryo transfer success rate(embryo implantation rate,clinical pregnancy rate,miscarriage rate,live birth rate)were compared between the two groups.Logistic regression analysis was used to adjust for possible interfering factors and evaluate the independent predictive effect of abnormal coagulation function on embryo transfer success rate.Results There was no statistically significant difference in general characteristics such as age,weight,underlying diseases,and ovulation induction protocols between the two groups(P>0.05).There were significant differences in INR,PT,APTT,D-dimer,antiphospholipid antibody positive and protein S deficiency between the two groups(P<0.05).The embryo implantation rate,clinical pregnancy rate,miscarriage rate and live birth rate in the abnormal coagulation function group were all lower than those in the normal coagulation function group,and the differences were statistically significant(P<0.05).Logistic regression analysis was used to adjust for possible interfering factors such as age,weight,and ovulation induction protocols,and the results showed that abnormal coagulation function remained an independent predictor of embryo transfer success rate.Conclusion Abnormal blood coagulation function significantly reduces the success rate of embryo transfer.Abnormal coagulation function has become an important independent predictor of embryo transfer success rate by affecting the embryo implantation rate,clinical pregnancy rate and live birth rate.Therefore,evaluating coagulation function before embryo transfer and adopting personalized treatment plans based on the types of coagulation abnormalities may help improve the success rate of embryo transfer.
作者
徐玲
赵自勇
王芳芳
XU Ling;ZHAO Zi-yong;WANG Fang-fang(Reproductive Medicine Center,988 Hospital,Joint Logistic Support Force,Jiaozuo,Henan,454150,China)
出处
《中国血液流变学杂志》
2025年第1期129-132,共4页
Chinese Journal of Hemorheology
关键词
胚胎移植
凝血功能异常
凝血因子
临床妊娠率
流产率
成功率
embryo transfer
coagulation dysfunction
coagulation factors
clinical pregnancy rate
miscarriage rate
success rate
