摘要
目的分析增强CT联合血清肿瘤标志物糖类抗原199(CA199)、血清肿瘤标志物癌胚抗原(CEA)、血清肿瘤标志物糖类抗原125(CA125)对胃癌腹膜转移的评估价值。方法纳入2020年3月至2024年3月期间收治的113例胃癌患者,对其临床资料进行回顾性分析,根据手术病理结果中是否发生腹膜转移分为无腹膜转移组(n=79)、腹膜转移组(n=34)。比较两组胃癌患者增强CT征象情况[浆膜外层不光整、淋巴结肿大、腹膜受累、腹腔积液]、增强CT检测参数[原发灶最大直径、胃壁增厚程度、病变强化程度]、CA199、CEA、CA125水平。以受试者工作曲线(ROC)评估增强CT参数联合CA199、CEA、CA125对胃癌腹膜转移的评估价值。结果腹膜转移组患者增强CT中浆膜外层不光整、淋巴结肿大、腹膜受累、腹腔积液发生率均显著高于无腹膜转移组(P<0.05);腹膜转移组患者原发灶最大直径、胃壁增厚程度、病变强化程度增强CT参数及CA199、CEA、CA125水平均显著高于无腹膜转移组(P<0.05)。ROC曲线中,增强CT参数联合CA199、CEA、CA125评估胃癌腹膜转移的曲线下面积(AUC)为0.931,敏感度为100.00%,特异度为69.62%。结论增强CT联合CA199、CEA、CA125评估胃癌腹膜转移中效能良好,可为临床治疗方案提供参考。
Objective To analyze the evaluated value of enhanced CT combined with serum tumor markers of carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)on peritoneal metastasis of gastric cancer.Methods 113 patients with gastric cancer were included from March 2020 to March 2024,and their clinical data were retrospectively analyzed.According to whether peritoneal metastasis occurred in the surgical pathology,they were divided into non-peritoneal metastasis group(n=79)and peritoneal metastasis group(n=34).The enhanced CT signs(uneven serosa outer layer,lymph node enlargement,peritoneal involvement,peritoneal effusion),enhanced CT detection parameters(maximum diameter of primary tumor,degree of gastric wall thickening,degree of lesion enhancement)and levels of CA199,CEA and CA125 were compared between groups.Receiver operating characteristic curve(ROC)was used to assess the evaluated value of enhanced CT parameters combined with CA199,CEA and CA125 on peritoneal metastasis of gastric cancer.Results The incidence rates of uneven serosa outer layer,lymph node enlargement,peritoneal involvement and peritoneal effusion in peritoneal metastasis group were significantly higher than those in non-peritoneal metastasis group(P<0.05).The enhanced CT parameters of maximum diameter of primary tumor,degree of gastric wall thickening and degree of lesion enhancement and levels of CA199,CEA and CA125 in peritoneal metastasis group were significantly higher than those in non-peritoneal metastasis group(P<0.05).Under the ROC curve,the area under the curve(AUC),sensitivity and specificity of enhanced CT parameters combined with CA199,CEA and CA125 in evaluating peritoneal metastasis of gastric cancer were 0.931,100.00%and 69.62%.Conclusion Enhanced CT combined with CA199,CEA and CA125 has good efficiency on evaluating peritoneal metastasis of gastric cancer,which can provide reference for clinical treatment regimen.
作者
尹俊吉
魏阳进
王大浒
赵顺伟
杨静
YIN Jun-ji;WEI Yang-jin;WANG Da-hu;ZHAO Shun-wei;YANG Jing(Department of Radiology,Pengzhou People's Hospital,Pengzhou 611930,Sichuan Province,China;Department of Clinical Laboratory,Pengzhou People's Hospital,Pengzhou 611930,Sichuan Province,China;Department of Gastrointestinal Surgery,Pengzhou People's Hospital,Pengzhou 611930,Sichuan Province,China)
出处
《中国CT和MRI杂志》
2025年第7期142-144,198,共4页
Chinese Journal of CT and MRI
关键词
增强CT
肿瘤标志物糖类抗原199
肿瘤标志物癌胚抗原
肿瘤标志物糖类抗原125
胃癌
腹膜转移
Enhanced CT
Tumor Marker Carbohydrate Antigen 199
Tumor Marker Carcinoembryonic Antigen
Tumor Marker Carbohydrate Antigen 125
Gastric Cancer
Peritoneal Metastasis
