摘要
环境中存在的各种致病病毒对人类的健康造成了极大的危害。高效、快速的病毒富集技术对于早期病毒的诊断和疾病预警、防控具有重要意义。然而,目前有关病毒富集的综述大多侧重于病毒的富集方法,对材料及装置的研究较少。从病毒的电荷特性、生化特性及尺寸等方面阐述了富集病毒的相关材料及装置,涉及冠状病毒、流感病毒、诺如病毒等。此外,结合实例对纳米材料在病毒富集中的应用潜力,尤其在空气传播病毒检测中的有效性进行了说明。同时,探讨了基于其他性质的病毒富集材料和装置,如通过蒸发去除溶剂达到富集目的的方法。最后,探讨了微流控芯片在病毒富集领域的技术优化和应用前景,旨在为后续研究提供理论参考。
The various pathogenic viruses present in the environment pose a great threat to human health.Efficient and rapid virus enrichment technology is of great importance for early virus diagnosis,disease warning,prevention and control.However,current reviews on virus enrichment mostly focus on methods,with less research on materials and devices.This review elaborates on the relevant materials and devices for enriching viruses from the aspects of their charge characteristics,biochemical characteristics and size,involving coronaviruses,influenza viruses,norovirus,etc.This review introduces the potential application of nanomaterials in virus enrichment and demonstrates their effectiveness in detecting airborne viruses through examples.Meanwhile,we explore virus enrichment materials and devices based on other properties,such as methods of achieving enrichment by evaporating solvents.Finally,the technical optimization and application prospects of microfluidic chips in the field of virus enrichment are discussed,aiming to provide theoretical references for subsequent studies.
作者
张戈
敖青
周雪雁
丁功涛
王子凡
TEOW Yeit Haan
MOHD Shaiful Sajab
马忠仁
李志强
赵蕾
ZHANG Ge;AO Qing;ZHOU Xueyan;DING Gongtao;WANG Zifan;TEOW Yeit Haan;MOHD Shaiful Sajab;MA Zhongren;LI Zhiqiang;ZHAO Lei(Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;School of Life Sciences and Engineering,Northwest Minzu University,Lanzhou 730030,China;Faculty of Engineering and Built Environment,The National University of Malaysia,Bangi 43600,Malaysia;Key Laboratory of National Civil Affairs Commission of Stomatological Hospital,Northwest Minzu University,Lanzhou 730030,China)
出处
《中国材料进展》
北大核心
2025年第7期673-683,共11页
Materials China
基金
国家自然科学基金青年项目(22104045)
甘肃省自然科学基金项目(23JRRA1733)。
关键词
病毒富集
材料及装置
病毒表面电荷
特异性蛋白
病毒尺寸
virus enrichment
materials and devices
virus surface charge
specific proteins
virus size
