摘要
功能性便秘(FC)是一种常见的功能性肠病,肠道微生态失衡与FC发病密切相关。“肝肠轴”是指肝脏和肠道通过门静脉系统紧密联系在一起,在免疫、代谢与防御等方面相互联系、相互协作。中医学认为,肝与大肠之间有着密切的联系。肝之气血运行受到大肠的影响,而大肠传导之功也受到肝之疏泄的调控,与现代医学肝肠轴相吻合。肝肠轴与肠道微生态的关联主要体现在其对肠道菌群的调节、肠黏膜屏障及免疫炎症反应的调节。本研究基于“肝肠轴”探讨穴位埋线通过调节肠道微生态来治疗FC,阐明其作用机制及应用价值,以期为FC的治疗提供新的理论依据和临床指导。
Functional constipation(FC)is a common functional gastrointestinal disorder,and an imbalance in the intestinal microecology is closely associated with its pathogenesis.The‘gut-liver axis’refers to the close connection between the liver and the intestines via the portal venous system,through which they interact and cooperate in immune regulation,metabolism,and host defense.Traditional Chinese medicine also recognizes a close relationship between the Liver and the Large Intestine.The flow of Liver-Qi and blood is influenced by the Large Intestine,while the Large Intestine’s transport function is regulated by the Liver’s function of dispersing and dredging.This view aligns with the modern concept of the gut-liver axis.The gut-liver axis is closely related to intestinal microecology,mainly through its regulation of the gut microbiota,intestinal mucosal barrier,and immune-inflammatory responses.Based on the gut-liver axis,this study explores the mechanism and therapeutic value of acupoint catgut embedding in treating FC by regulating intestinal microecology,aiming to provide new theoretical support and clinical guidance for the treatment of FC.
作者
冯金宇
张雨祺
张筱慧
王家恩
王晓燕
FENG Jinyu;ZHANG Yuqi;ZHANG Xiaohui;WANG Jiaen;WANG Xiaoyan(School of Acupuncture-Moxibustion and Tuina,Shandong University of Traditional Chinese Medicine,Jinan 250013,China)
出处
《针灸临床杂志》
2025年第6期106-110,共5页
Journal of Clinical Acupuncture and Moxibustion
基金
山东省自然科学基金面上项目,编号:ZR2022MH149
齐鲁医派中医学术流派传承项目,编号:2022-02-038
山东省中医药科技项目,编号:M-2023072
山东大学临床医学科技创新计划,编号:202225072。
关键词
功能性便秘
穴位埋线
肝肠轴
肠道微生态
Functional constipation
Acupoint catgut embedding
Liver-intestinal axis
Intestinal mic-roecology
