摘要
The accumulation of deoxyribonucleic acid(DNA)oxidative damage mediated by reactive oxygen species(ROS)is closely associated with liver diseases.8-Oxoguanine(8-OxoG),a prevalent DNA oxidation product,plays a significant role in liver disease progression.The base excision repair(BER)pathway,comprising over 30 proteins including 8-OxoG DNA glycosylase1(OGG1),MutY homolog(MUTYH),and MutT homolog protein 1(MTH1),is responsible for the clearance and mismatch repair of 8-OxoG.Abnormally high levels of 8-OxoG and dysregulated expression and function of 8-OxoG repair enzymes contribute to the onset and development of liver diseases.Consequently,targeting the 8-OxoG production and repair system with agonists or inhibitors may offer a promising approach to liver disease treatment.This review summarizes the impact of 8-OxoG accumulation and dysregulated repair enzymes on various liver diseases,including viral liver disease,alcoholic liver disease(ALD),metabolic dysfunction-associated steatotic liver disease(MASLD),cholestatic liver disease(CLD),liver fibrosis,cirrhosis,and liver cancer.Additionally,we review natural constituents as potential therapeutic agents that regulate 8-OxoG production,repair enzymes,and repair system-related signal pathways in oxidative damage-induced liver diseases.
基金
supported by the National Key R&D Program of China(No.2023YFD1601400)
the National Natural Science Foundation of China(Nos.82373912 and 82074068)
Jiangsu Outstanding Youth Fund Project(No.BK20231535)
the Fundamental Research Funds for the Central Universities(No.2632022YC04).
