摘要
目的:观察自拟消脂散加减对获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)抗逆转录病毒(antiretroviral therapy,ART)干预后高脂血症患者的影响。方法:选取某省中医药治疗项目单位的AIDS患者421例,随机分为观察组(209例)和对照组(212例)。对照组采用抗病毒药物加瑞舒伐他汀钙治疗,观察组在对照组基础上联合自拟消脂散加减治疗。比较两组患者CD4+T淋巴细胞值、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)。结果:与治疗前比较,观察组和对照组治疗3、6、12个月CD4+T淋巴细胞值增高(P<0.05),观察组治疗3、6个月CD4+T淋巴细胞值高于对照组,差异有统计学意义(P<0.05)。观察组治疗第2、4周后TG、TC和LDL-C降低(P<0.05),对照组治疗第2周降低(P<0.05);治疗第2、4周观察组TG、TC和LDL-C优于对照组(P<0.05)。结论:自拟消脂散加减能改善AIDS患者血脂水平,辅助提升CD4+T淋巴细胞水平。
Objective:To explore the influence of modified fat-lowering powder on hyperlipidemia patients after intervention with antiretroviral therapy(ART)for AIDS.Methods:A total of 421 AIDS patients were chosen from a provincial TCM treatment project unit,and randomized into the observation group(209 cases)and the control group(212 cases).The control group was treated with antiviral drug and rosuvastatin calcium,and the observation group took modified fat-lowering powder orally based on the therapy of the control group.To compare the levels of CD4+T lymphocytes,TG,TC and LDL-C between the two groups.Results:Compared with before the treatment,the values of CD4+T lymphocytes were elevated in the observation group and the control group after treating for three,six and twelve months(P<0.05),the values of CD4+T lymphocytes in the observation group were higher than these of the control group after three and six months of treatment,and the difference had statistical meaning(P<0.05).The levels of TG,TC and LDL-C were reduced in the observation group after two and four weeks of the treatment(P<0.05),and these indexes were lowered in the control group after two weeks of the treatment(P<0.05);the levels of TG,TC and LDL-C of the observation group were better than these of the control group(P<0.05).Conclusion:Self-made fat-lowering powder could improve the levels of blood lipid in AIDS patients and enhance the levels of CD4+T lymphocytes.
作者
何琼
孙建云
高晓东
陈发青
寇翠萍
HE Qiong;SUN Jianyun;GAO Xiaodong;CHEN Faqing;KOU Cuiping(Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,China)
出处
《西部中医药》
2025年第6期141-144,共4页
Western Journal of Traditional Chinese Medicine
基金
甘肃省自然科学基金(23JRRA1255)。
