摘要
早发性卵巢功能不全(premature ovarian insufficiency,POI)发病机制尚不完全清楚,内分泌干扰物暴露可能与POI发生发展密切相关。皂苷、黄酮、多酚和多糖等中药活性成分可通过恢复氧化还原稳态、减轻卵巢炎症、改善自噬和凋亡、调节激素等途径有效减缓甚至逆转内分泌干扰物对卵巢功能的胁迫效应。通过相关文献分析总结,对中药及其活性成分干预内分泌干扰物致POI的作用与机制进行综述,以期为女性生育力保护和POI治疗提供参考。
The etiology of premature ovarian insufficiency(POI)remains incompletely understood,but there is evidence suggesting a close association between exposure to endocrine-disrupting chemicals(EDCs)and the onset and progression of POI.Recent research has indicated that active components found in traditional Chinese medicine,such as saponins,flavonoids,polyphenols,and polysaccharides,may effectively counteract the adverse effects of EDCs on ovarian function by restoring redox homeostasis,reducing ovarian inflammation,improving autophagy and apoptosis processes,and regulating hormone levels.Through the analysis and summary of relevant literature,the roles and mechanisms of traditional Chinese medicine and its active components in mitigating EDC-induced POI were discussed,with the aim of offering insights for female fertility preservation and POI treatment.
作者
丁一柠
陈瑾
DING Yining;CHEN Jin(Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《现代中医药》
2025年第4期8-13,共6页
Modern Chinese Medicine
基金
浙江省大学生创新创业训练计划项目(S202310344124)。
关键词
人参
菟丝子
枸杞子
内分泌干扰物
早发性卵巢功能不全
panax ginseng
cuscuta chinensis
lycium barbarum
endocrine disrupting chemicals
premature ovarian insufficiency
