摘要
全身麻醉已在临床中广泛应用,但全身麻醉药物导致可逆性意识消失的具体机制仍未被完全阐明。近年来大量研究显示,全身麻醉药物所致意识消失可能与多巴胺能系统密切相关。脑内多巴胺能系统主要包括多巴胺能神经元、多巴胺受体以及相关的神经通路,参与运动、记忆、觉醒和认知等功能的调控。其中,腹侧导水管周围灰质和腹侧被盖区中的多巴胺能神经元以及D1类受体可促进全身麻醉状态下的苏醒过程,但D2类受体的作用仍存在争议。本文系统综述了多巴胺能系统在全身麻醉中的作用及其分子机制,为深入探讨全身麻醉的机制以及预防术后苏醒延迟提供理论依据。
General anesthesia is widely used in clinical practice,whereas the exact mechanism behind the general anesthetic-induced reversible loss of consciousness remains unclear.Recent studies have revealed a close relationship between the dopaminergic system and general anesthetic-induced loss of consciousness.This system,encompassing dopamine neurons,dopamine receptors,and related neural pathways,regulates functions such as movement,memory,arousal,and cognition.The dopaminergic neurons in the ventral periaqueductal gray and ventral tegmental area,along with D1 receptors,have been shown to facilitate emergence from anesthesia.However,the role of D2 receptors remains controversial.This review summarizes recent advancements in the role of the dopaminergic system in general anesthesia and the underlying mechanism,with the aim of clarifying the mechanism of general anesthesia and providing a theoretical basis for preventing delayed emergence from anesthesia.
作者
罗薇
袁城栋
郝孟楠
张洁
张益
LUO Wei;YUAN Chengdong;HAO Mengnan;ZHANG Jie;ZHANG Yi(Department of Anesthesiology,The Second Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;Key Laboratory of Anesthesia and Organ Protection of Guizhou Province,Zunyi Medical University,Zunyi,Guizhou 563000,China)
出处
《中国医学科学院学报》
北大核心
2025年第3期441-446,共6页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(82360709)
贵州省科学技术厅项目[黔科合基础-ZK〔2024〕一般343、黔科合基础-ZK〔2023〕一般528]
贵州省研究生科研基金(2024YJSKYJJ331)
贵州省高层次创新人才“千层次”人才项目。
