摘要
目的探究分化型甲状腺癌伴淋巴结转移术后患者接受碘-131治疗的疗效及其影响因素。方法择取本院50例分化型甲状腺癌伴淋巴结转移术后患者(2022年1月—2025年1月)深入分析,术后采用碘-131治疗,观察临床疗效,依据治疗情况分为有效组(39例)与无效组(11例),同时分析其影响因素。结果在对50例分化型甲状腺癌并伴有淋巴结转移的患者进行碘-131治疗后,39例患者治疗效果显著,其有效率达到78.00%,而另外11例患者治疗效果不显著,无效率为22.00%。有效组与无效组在性别、手术方式、胸部X光片及CT影像表现、颈部淋巴结转移/病理学类型、显像时机、摄碘-131对比,差异无统计学意义(P>0.05);然而,在年龄、血管内皮生长因子(VEGF)水平、合并其他转移病灶方面,差异有统计学意义(P<0.05)。进一步的Logistic回归分析揭示,年龄、VEGF水平、合并其他转移病灶是影响临床治疗效果的关键因素。结论对分化型甲状腺癌伴淋巴结转移术后患者治疗时,碘-131临床疗效显著,其年龄、VEGF、合并其他转移病灶因素可对治疗效果造成一定影响,因此治疗前可通过控制相关影响因素提升治疗效果。
Objective To explore the efficacy of iodine-131 treatment after differentiated thyroid cancer with lymph node metastasis.Methods Fifty cases of differentiated thyroid cancer with lymph node metastasis in our hospital(January 2022 to January 2025)were selected for in-depth analysis.After operation,they were treated with iodine-131,and the clinical efficacy was observed.According to the treatment,they were divided into effective group(39 cases)and ineffective group(11 cases),and the influencing factors were analyzed.Results After treatment,there were 50 patients with remarkable effect,the effective rate was 78.00%,and 5 patients with no significant effect after treatment,the ineffective rate was 22.00%.There was no difference between the effective group and the ineffective group in sex,operation mode,good CT display of chest film,cervical lymph node metastasis/pathological type,imaging opportunity and iodine-131 intake(P>0.05).There were differences in age,VEGF and other metastatic lesions between the two groups(P<0.05).Logistic regression analysis showed that age,VEGF and other metastatic lesions were the influencing factors of clinical treatment effect.Conclusion Iodine-131 has significant clinical effect in patients with differentiated thyroid cancer with lymph node metastasis,and its age,VE GF and other metastatic factors can affect the treatment effect,so the treatment effect can be improved by controlling related influencing factors before treatment.
作者
李继秀
张金风
LI Jixiu;ZHANG Jinfeng(Jiugang Hospital,Jiayuguan,Gansu 735100)
出处
《智慧健康》
2025年第11期106-109,共4页
Smart Healthcare
基金
嘉峪关市科学技术局《分化型甲状腺癌伴淋巴结转移术后碘-131治疗的疗效观察及风险因素分析研究(B)类》(项目编号:23-B09)。
关键词
分化型甲状腺癌
淋巴结转移
碘-131
影响因素
Differentiated thyroid cancer
Lymph node metastasis
Iodine-131
Influencing factors
