摘要
目的观察针刺治疗寒热错杂型胃食管反流病(Gastro-esophageal reflux disease,GERD)的临床疗效。方法选取2022年4月—2024年2月北京中医药大学东直门医院收治的GERD患者46例,按随机数字表法分为对照组和治疗组,每组各23例。治疗组给予针刺曲泉,神门,内关,足三里,巨阙,中脘,关元。留针20 min,每周2次,间隔2~3 d。对照组口服雷贝拉唑钠肠溶胶囊,20 mg/次,1次/d,两组患者均治疗8周。观察比较两组患者的临床疗效、不良反应情况及复发率,治疗前后反流性疾病问卷量表(Reflux diagnostic questionnaire,RDQ)、中医证候量表评分。结果治疗后治疗组临床总有效率86.96%(20/23)与对照组78.26%(18/23)比较,差异无统计学意义(P>0.05)。治疗后两组患者RDQ评分均较治疗前降低,差异有统计学意义(P<0.05);两组间RDQ评分比较,差异无统计学意义(P>0.05)。治疗后两组患者主症评分均较治疗前降低,治疗组次症评分较治疗前降低,差异有统计学意义(P<0.05),对照组次症评分较治疗前无明显变化,差异无统计学意义(P>0.05);且治疗组次症评分较对照组明显降低,差异有统计学意义(P<0.05),主症评分与对照组比较无明显变化,差异无统计学意义(P>0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗结束后4周随访,治疗组无复发,对照组复发率为72.2%(13/18),两组间比较差异有统计学意义(P<0.05)。结论针刺治疗寒热错杂型GERD可明显减轻主要症状,治疗总有效率与口服雷贝拉唑相当,复发率明显低于对照组,且疗效更持久。
Objective To evaluate the clinical efficacy of acupuncture in the treatment of gastroesophageal reflux disease(GERD)of cold and heat in complexity type.Methods A total of 46 GERD patients treated at Dongzhimen Hospital,Beijing University of Chinese Medicine,from April 2022 to February 2024 were enrolled and randomly divided into a treatment group and a control group according to a random number table,with 23 patients in each group.The treatment group received acupuncture at Ququan(LR8),Shenmen(HT7),Neiguan(PC6),Zusanli(ST36),Juque(CV14),Zhongwan(CV12),and Guanyuan(CV4),with needles retained for 20 min,twice a week,at intervals of 2-3 days.The control group was treated with oral rabeprazole sodium enteric-coated capsules,20 mg once daily.Both groups were treated for 8 weeks.Clinical efficacy,adverse reactions,recurrence rate,Reflux Diagnostic Questionnaire(RDQ)scores,and traditional Chinese medicine(TCM)syndrome scale scores of the two groups were observed and compared before and after treatment.Results After treatment,the total clinical effective rate was 86.96%(20/23)in the treatment group and 78.26%(18/23)in the control group,with no statistically significant difference(P>0.05).RDQ scores significantly decreased in both groups after treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).After treatment,the primary symptom scores in both groups decreased significantly compared to baseline(P<0.05),and the secondary symptom scores in the treatment group also decreased significantly(P<0.05),while no significant change of secondary symptom scores was observed in the control group(P>0.05).Moreover,the reduction in secondary symptom scores was significantly greater in the treatment group than in the control group(P<0.05),whereas the primary symptom scores showed no significant difference between groups(P>0.05).The incidence of adverse reactions during treatment showed no statistically significant difference between the two groups(P>0.05).At the 4-week follow-up after treatment,no recurrence was observed in the treatment group,while the recurrence rate was 72.2%(13/18)in the control group,with a statistically significant difference between the two groups(P<0.05).Conclusion Acupuncture treatment for GERD of cold and heat in complexity type can significantly alleviate primary symptoms,with a total efficacy comparable to that of oral rabeprazole.Moreover,it demonstrates a significantly lower recurrence rate and more sustained therapeutic effect than the control group.
作者
金昕
许月
王露露
徐祯谦
赵茹薇
陈晟
JIN Xin;XU Yue;WANG Lu-lu;XU Zhen-qian;ZHAO Ru-wei;CHEN Sheng(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700;Beijing Dongcheng District Hospital of Traditional Chinese Medicine,Beijing 100013)
出处
《世界中西医结合杂志》
2025年第6期1232-1236,共5页
World Journal of Integrated Traditional and Western Medicine
基金
北京市中医药科技发展资金项目(BJZYQN-2023-15)。
关键词
胃食管反流病
针刺
寒热错杂
Gastroesophageal Reflux Disease
Acupuncture
Cold and Heat in Complexity
