摘要
目的观察五子散外敷辅助治疗糖尿病肾病(Diabetic nephropathy,DN)患者胃肠道症状的临床效果。方法选取2022年1月—2023年12月泰州市中医院肾病科收治的DN合并消化道症状患者60例,按随机数字表法分为对照组和治疗组,每组各30例。两组患者均给予肾脏内科常规治疗,包括胃黏膜营养治疗、改善贫血、维持钾离子治疗,同时口服或静脉滴注碳酸氢钠,治疗组在对照组的基础上加用五子散外敷。两组患者均治疗两个疗程,两周为1个疗程。观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候积分、胃肠道症状评定量表(Gastrointestinal symptom rating scale,GSRS)评分。结果治疗后治疗组临床总有效率90.00%(27/30)高于对照组63.33%(19/30),差异有统计学意义(P<0.05)。治疗后两组患者中医证候评分均较治疗前降低,差异有统计学意义(P<0.01);且治疗组中医证候评分低于对照组,差异有统计学意义(P<0.01)。治疗后两组患者GSRS评分均较治疗前降低,差异有统计学意义(P<0.01);且治疗组GSRS评分低于对照组,差异有统计学意义(P<0.01)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论五子散外敷法可提高DN患者临床治疗有效率,改善胃肠道症状评分,同时并未增加治疗不良反应。
Objective To explore the clinical efficacy of Wuzi powder external application in adjunctively treating gastrointestinal symptoms in patients with diabetic nephropathy(DN).Methods Sixty patients with DN complicated with gastrointestinal symptoms admitted to the nephrology department of Taizhou Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were selected and randomly divided into a control group and a treatment group by random number table method,with 30 cases in each group.Patients in both groups were given conventional internal medicine treatment,including gastric mucosal nutrition treatment,anemia improvement,and calcium ion maintenance.In contrast,the treatment group was supplemented with the external application of Wuzi powder.The treatment lasted for two courses in both groups(each course included two weeks).After treatment,the following aspects were compared between the two groups:clinical efficacy,traditional Chinese medicine(TCM)syndrome scores before and after treatment,gastrointestinal symptom rating scale(GSRS),and adverse reactions.Results After treatment,the total clinical efficacy of the treatment group was 90.00%(27/30),higher than 63.33%(19/30)of the control group,and the difference was statistically significant(P<0.05).The TCM syndrome scores of the two groups were significantly lower(P<0.01),with the scores lower in the treatment group(P<0.01).The GSRS scores of the two groups after treatment were lower(P<0.01),with the GSRS scores lower in the treatment group(P<0.01).There was no significant difference between the two groups in the incidence of adverse reactions(P>0.05).Conclusion External application of Wuzi powder can improve the clinical efficacy in DN patients by improving the gastrointestinal symptom scores while not increasing the adverse reaction.Therefore,it can be recommended for clinical use.
作者
许照
周燕
王平
马腾
叶海亮
周志伟
于亚萍
XU Zhao;ZHOU Yan;WANG Ping;MA Teng;Ye Hai-liang;ZHOU Zhi-wei;YU Ya-ping(Taizhou Hospital of Traditional Chinese Medicine,Taizhou Jiangsu 225399;Jiangsu Provincial Hospital,Nanjing Jiangsu 210029)
出处
《世界中西医结合杂志》
2025年第6期1207-1210,共4页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省中医药科技发展计划项目(YB201983)。
关键词
糖尿病肾病
胃肠道反应
五子散外敷
中医评分
Diabetic Nephropathy
Gastrointestinal Reaction
Wuzi Powder External Application
TCM Score
