摘要
目的分析胃癌组织微小RNA-181d-5p、蛋白磷酸酶2A(PP2A)与患者术后5 a内生存相关性。方法选择安阳市肿瘤医院于2018年6月至2019年6月收治的96例接受根治性手术治疗胃癌患者为研究对象。术中收集患者的胃癌组织标本及癌旁正常组织。分别检测微小RNA-181d-5p和PP2A表达。术后随访5 a,记录患者的生存情况。对比胃癌组织标本及癌旁正常组织微小RNA-181d-5p、PP2A表达水平、不同临床病理特征患者胃癌组织微小RNA-181d-5p、PP2A表达情况、不同预后患者微小RNA-181d-5p、PP2A表达水平情况。探究胃癌组织微小RNA-181d-5p、PP2A表达与临床病理特征的相关性。结果与癌旁正常组织相比,胃癌组织标本微小RNA-181d-5p较高,PP2A较低(P<0.05);微小RNA-181d-5p的高表达组与低表达组、PP2A的阳性表达组与阴性表达组在肿瘤分化程度、浸润深度、淋巴结转移、TNM分期差异有统计学意义(P<0.05);在年龄、性别、肿瘤直径方面差异无统计学意义(P>0.05);影响术后5 a内生存的因素有肿瘤分化程度、浸润深度、淋巴结转移、TNM分期、微小RNA-181d-5p、PP2A(P<0.05)。微小RNA-181d-5p与肿瘤分化程度呈负相关,与浸润深度、淋巴结转移、TNM分期呈正相关(P<0.05);PP2A与肿瘤分化程度呈正相关,与浸润深度、淋巴结转移、TNM分期呈负相关(P<0.05)。结论微小RNA-181d-5p、PP2A表达与胃癌发生发展关系密切,微小RNA-181d-5p表达较高、PP2A表达降低的胃癌患者,术后复发及转移的风险较高,生存期较短,对预测术后5 a生存情况价值较高。
Objective To analyze the correlation between gastric cancer tissue microRNA-181d-5p,protein phosphatase 2A(PP2A)and survival within 5 years after surgery.Methods A total of 96 patients with gastric cancer who underwent radical surgery in Anyang Cancer Hospital from June 2018 to June 2019 were selected as the research subjects.Gastric cancer tissue samples and adjacent normal tissues were collected during the operation.The of microRNA-181d-5p and PP2A was detected.The patients were followed up for 5 years after the operation,and their status was recorded.Results Compared with the adjacent normal tissues,expression of microRNA-181d-5p of the gastric cancer tissue samples was higher and PP2A was lower(P<0.05).There were significant differences between the high expression group of microRNA-181d-5p and the low expression group,and the positive expression group of PP2A and the negative expression group in tumor differentiation degree,invasion depth,lymph node metastasis and TNM stage(P<0.05).There were no significant differences in age,sex and tumor diameter(P>0.05).The factors affecting survival within 5 years surgery include tumor differentiation,invasion depth,lymph node metastasis,TNM stage(P<0.05).microRNA-181d-5p was negatively correlated with the degree of tumor differentiation,but positively correlated with the depth of invasion,lymph node metastasis and TNM stage,microRNA-181d-5p and PP2A(P<0.05).PP2A was positively correlated with the degree of tumor differentiation,but negatively correlated with invasion depth,lymph node metastasis and TNM stage(P<0.05).Conclusion The expression of microRNA-181d-5p and PP2A is closely related to the occurrence and development of gastric cancer.Gastric cancer patients with higher expression of microRNA-181d-5p and lower expression of PP2A have a higher risk of postoperative recurrence and metastasis and a shorter survival period,which is of high value in predicting 5-year postoperative survival.
作者
刘菁
王君
谷华伟
LIU Jing;WANG Jun;GU Huawei(Department of Pharmacy,Anyang Cancer Hospital,Anyang 455000,China)
出处
《河南医学研究》
2025年第13期2383-2387,共5页
Henan Medical Research
基金
安阳市2022年科技发展计划(2022C01SF026)。
