摘要
目的探讨超重及肥胖人群血小板分布宽度(PDW)与冠状动脉钙化(CAC)的相关性。方法回顾性分析10838例超重或肥胖[体质量指数(BMI)≥24 kg/m^(2)]者临床及胸部CT资料,根据基于胸部CT所获CAC评分将其分为CAC组(n=4237)与非CAC组(n=6601);控制混杂变量后,分析超重及肥胖者PDW与CAC的关系,以两阶段logistic模型进行阈值效应分析,寻找非线性拐点,通过亚组分析和交互作用检验观察上述关系的稳定性。结果超重及肥胖者PDW与CAC风险呈非线性关系:PDW≤17.80%时,随PDW升高,CAC风险降低(OR=0.82);PDW>17.80%时,随PDW升高,CAC风险亦升高(OR=1.04)。亚组分析结果显示,不同性别、BMI(<28 kg/m^(2)、≥28 kg/m^(2))及有无高血压亚组中,PDW与CAC关系均保持稳定(P均>0.05);相同PDW下,相比年龄<40岁及≥60岁亚组,≥40且<60岁亚组CAC风险更高(交互作用P=0.015)。结论超重及肥胖者PDW与CAC呈非线性相关;其PDW过高或过低均为CAC危险因素。
Objective To investigate the relationship between platelet distribution width(PDW)and coronary artery calcification(CAC)in overweight and obese populations.Methods Clinical and chest CT data of 10838 subjects with overweight or obesity(body mass index[BMI]≥24 kg/m^(2))were retrospectively analyzed.The subjects were divided into CAC group(n=4237)and non-CAC group(n=6601)based on CAC scores obtained from chest CT.The relationship between PDW and CAC in overweight and obese populations was analyzed after controlling confounding variables.A threshold effect analysis was conducted using a two-stage logistic model to find the non-linear inflection point.Subgroup analyses and interaction tests were conducted to validate the stability of the relationship between PDW and CAC.Results Non-linear relationship was observed between PDW and CAC risk in overweight and obese populations.The risk of CAC decreased with the increase of PDW which≤17.80%(OR=0.82),but increased with the increase of PDW(OR=1.04)which>17.80%.Subgroup analysis showed that the relationship between PDW and CAC remained stable in subgroups of different genders,BMI(<28 kg/m^(2),≥28 kg/m^(2))and hypertension(all P>0.05).Compared with aged<40 years or≥60 years subgroups,under the same PDW,aged≥40 and<60 years subgroups had higher risk of CAC(interaction P=0.015).Conclusion Nonlinear relationship existed between PDW and CAC in overweight and obese populations.Both excessively high and low PDW were risk factors of CAC.
作者
王晨一
孙永兵
邹智
李中林
武肖玲
尚菲菲
屈敏
张潇琳
朱嘉栋
仝春实
李永丽
WANG Chenyi;SUN Yongbing;ZOU Zhi;LI Zhonglin;WU Xiaoling;SHANG Feifei;QU Min;ZHANG Xiaolin;ZHU Jiadong;TONG Chunshi;LI Yongli(Department of Medical Imaging,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Nuclear Medicine,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,Henan Provincial Key Laboratory of Chronic Disease Health Management,Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Oral Surgery,Henan Provincial People's Hospital,Zhengzhou 450003,China)
出处
《中国医学影像技术》
北大核心
2025年第6期914-918,共5页
Chinese Journal of Medical Imaging Technology
基金
河南省重点研发专项资助项目(251111312900)
河南省科技攻关计划项目(252102310050)
河南省高等学校重点科研项目(25A310026)。
关键词
肥胖
血小板
冠状动脉狭窄
obesity
blood platelets
coronary stenosis
